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http://dx.doi.org/10.1016/j.hrthm.2024.10.036 | DOI Listing |
J Steroid Biochem Mol Biol
September 2025
Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia. Electronic address:
Vitamin D has been proposed to attenuate chemotherapy-induced gastrointestinal mucositis (GM). In the intestine, local catabolism of active vitamin D [1,25-dihydroxyvitamin D₃] is mediated by the enzyme Cyp24a1. This study assessed whether deletion of Cyp24a1 specifically in intestinal epithelial cells can protect against 5-fluorouracil (5-FU)-induced intestinal injury and microbiome disruption in mice.
View Article and Find Full Text PDFFood Chem
August 2025
College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China; State Key Laboratory of Soil Pollution Control and Safety, Zhejiang University, Hangzhou 310058, China; Innovation Center of Yangtze River Delta, Zhejiang University, Jiaxing 314102, China. Electronic addres
This study investigated the spatial distribution of Cd and mineral nutrients (Mg, P, K, Ca, Mn, Fe, Cu, Zn) in rice grains from low-Cd accumulating (LA) and high-Cd accumulating (HA) cultivars using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). Cd concentrations were significantly higher in HA than LA cultivars across polished rice, brown rice, and husks. Spatial mapping demonstrated Cd was distributed in the outer endosperm/embryo of LA grains, but preferentially enriched in the embryo and aleurone layer of HA grains.
View Article and Find Full Text PDFJ Pharmacol Exp Ther
August 2025
Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; Center for Immunology
We evaluated the antitumor effects of remodeling the MC17 mouse sarcoma microenvironment (SME) by targeting urokinase-type plasminogen activator receptor (uPAR)- and epidermal growth factor receptor (EGFR)-expressing cells. Specifically, we used eBAT (a bispecific ligand-targeted toxin directed to EGFR and uPAR), and its mouse counterpart, meBAT, to ablate uPAR- and/or EGFR-expressing cells. We chose the MC17 model because the cells are resistant to eBAT, allowing us to exclusively evaluate the role of uPAR- and EGFR-expressing cells in the SME.
View Article and Find Full Text PDFLife Sci
September 2025
Department of Experimental Medical Science, Faculty of Medicine, Lund University, 221 84, Lund, Sweden; Wallenberg Center for Molecular Medicine, Faculty of Medicine, Lund University, 221 84, Lund, Sweden. Electronic address:
Aims: Experimental evidence suggests an important role for sphingosine-1-phosphate (S1P) and its generating enzymes sphingosine kinase 1/2 (SphK1/2) in obesity. We and others have shown that plasma S1P levels are elevated in obese mice and humans. Preclinical studies suggest that genetic SphK2 ablation in mice protects from age- and diet-induced obesity and metabolic dysfunction.
View Article and Find Full Text PDFBMJ Open
September 2025
Department of Nursing, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
Introduction: Atrial fibrillation (AF) is the most common cardiac arrhythmia, significantly affecting patients' quality of life (QoL) and increasing the risk of complications such as heart failure, stroke and dementia. In addition to the physical burden, psychological distress, including depression and anxiety, is prevalent among patients with AF and can exacerbate clinical symptoms and worsen overall well-being. While radiofrequency ablation (RFA) is widely used for rhythm control in AF, its long-term effects on both physical and psychological outcomes, including symptom severity, anxiety, depression and QoL, remain underexplored.
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