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Basal cell carcinomas (BCCs) are slow-growing keratinocyte tumours. There are few reports in the literature reporting the natural history of untreated BCCs. We evaluated the natural progression of BCCs and patient outcomes while awaiting surgical intervention. Only patients with histologically proven BCCs were included in our analysis. Retrospective data analysis was performed for a sample of 55 patients (in total, 70 lesions). There was a significant correlation between the average growth of BCCs and the time waiting for a procedure, with 20% of patients requiring a more complex procedure than originally planned at the time of booking. The top three most frequently reported symptoms were itching (39.4%), crusting (36.4%) and bleeding (30.3%). We report a positive relationship between BCC growth and the length of time from initial presentation to surgical treatment. Patients with long waits often exhibited more symptoms and required more complex surgical procedures than originally planned, especially for BCCs in the head and neck.
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http://dx.doi.org/10.1093/ced/llae460 | DOI Listing |
Macromol Biosci
September 2025
Department of Chemistry and Biochemistry, Concordia University, Montreal, Quebec, Canada.
Timely and accurate assessment of wounds during the healing process is crucial for proper diagnosis and treatment. Conventional wound dressings lack both real-time monitoring capabilities and active therapeutic functionalities, limiting their effectiveness in dynamic wound environments. Herein, we report our proof-of-concept approach exploring the unique emission properties and antimicrobial activities of carbon nanodots (CNDs) for simultaneous detection and treatment of bacteria.
View Article and Find Full Text PDFNeurosurg Rev
September 2025
Department of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany.
Purpose: To share our clinical experience with conservative management of isolated spinal arterial aneurysms (ISAs) and to identify clinical scenarios where conservative management may be appropriate, in the context of a literature review.
Methods: We performed a retrospective review of spinal angiograms from two German neuroradiology centers and conducted a systematic literature review of reported ISA cases. We analyzed demographics, clinical presentation, imaging findings, treatments, and outcomes.
Adv Mater
September 2025
College of Chemistry, Zhengzhou University, 100 Science Road, Zhengzhou, 450001, P. R. China.
Formic acid (FA) has attracted significant interest as a renewable liquid-phase hydrogen carrier. Hydrogen generation from FA decomposition is essential for the development of hydrogen economy. Designing highly efficient catalysts with different coordination environments for FA dehydrogenation is crucial for fuel-cell applications.
View Article and Find Full Text PDFJ Extracell Vesicles
September 2025
Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Osteoarthritis (OA), the prevalent debilitating joint disorder, is accelerated by dysregulated intercellular crosstalk, yet the role of fibroblast-like synoviocyte (FLS)-derived extracellular vesicles and particles (EVPs) in disease progression remains to be elucidated. Here, integrative analysis of clinical specimens, animal models, and publicly available datasets revealed significant alterations in exosomal pathways within OA synovium. Proteomic profiling revealed distinct molecular signatures in EVPs derived from inflammatory and senescent FLSs, reflecting the pathophysiological status of their parent cells.
View Article and Find Full Text PDFMycoses
September 2025
Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Background: Mucormycosis is a rare, rapidly progressive fungal infection with a high mortality rate. However, clinical data of mucormycosis patients, especially those related to adverse outcomes in China, remain limited.
Objective: To enhance understanding of the clinical characteristics of different infection site mucormycosis and identify the factors associated with adverse outcomes.