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Background: The Depression Anxiety Stress Scale-21 Items (DASS-21) is commonly used to assess the mental health of students, but there is a need for further clarification regarding its equivalence, structure, and core items.
Methods: We conducted a confirmatory factor analysis (CFA) on a sample of 7943 Chinese students to examine the performance of the DASS-21 and assess measurement invariance. Additionally, we utilized network analysis to investigate the structure and centrality of students' mental health.
Results: Our findings revealed a stable three-factor structure for the DASS-21, characterized by high correlations among depression, anxiety, and stress. The DASS-21 demonstrated strict invariance across genders and weak invariance across levels of education. Network analysis indicated that symptoms of depression, anxiety, and stress form clusters, with some symptoms exhibiting strong correlations with each other.
Conclusion: Our study highlights a substantial interrelation among depression, anxiety, and stress, revealing a structurally clustered pattern. Network analysis underscores the interconnectedness and centrality of these symptoms, recommending a shorter version of the DASS, and emphasizing the imperative for targeted interventions aimed at improving the psychological well-being of students.
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http://dx.doi.org/10.1186/s12889-024-20123-6 | DOI Listing |
Sci China Life Sci
September 2025
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.
Hormones are important bioactive molecules that regulate the development, function, and homeostasis of tissues/organs via binding to hormone receptors (HRs) in target cells. Although human HRs are essential for both basic research and drug development, a comprehensive analysis of them is still lacking. Here, we present a systematic bioinformatic investigation of all known human HRs, characterizing their genomic distributions, biological functions, subcellular localizations, and expression patterns in various cell types and tissues/organs.
View Article and Find Full Text PDFJ Gen Intern Med
September 2025
Department of Family Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR, USA.
Background: Hypertension is the most prevalent reversible risk for cardiovascular morbidity and mortality. Blood pressure (BP) control is poor nationally and varies by race/ethnicity, and there is minimal understanding of the impact of country of origin.
Objective: To examine racial/ethnic disparities in BP control among high-risk patients and among Latino patients disaggregated by country of origin.
Mikrochim Acta
September 2025
College of Food Science and Engineering, Northwest A&F University, 22 Xinong Road, Yangling, 712100, Shaanxi, China.
Salmonella typhimurium (S. typhimurium) A dual-mode colorimetric/photothermal immunochromatographic strip (ICS) employing hollow polydopamine nanoparticles (h-PDA) is reported for the ultrasensitive detection of Salmonella typhimurium (S. typhimurium).
View Article and Find Full Text PDFJ Mol Histol
September 2025
Hebei Medical University, No. 361, Zhongshan East Road, Shijiazhuang, 050017, China.
Numerous people experiencing acute myocardial infarction are also experiencing myocardial ischemia-reperfusion injury (MIRI). Pyroptosis is a core mechanism in MIRI. Tongxinluo (TXL) has a significant protective effect on endothelial cell function.
View Article and Find Full Text PDFMol Psychiatry
September 2025
Research Group Cognition and Plasticity, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Background: Peripartum depression (PPD) is a form of major depressive disorder (MDD) that begins during the peripartum period and poses a significant mental health challenge affecting 10 to 29% of women.
Objective: This systematic review and multimodal activation likelihood estimation (ALE) meta-analysis explored the distinct structural, functional, and metabolic features of the PPD brain as compared to female non-peripartum MDD.
Methods: For this purpose, we conducted a comprehensive literature search in PubMed, Embase and PsycINFO databases to identify peer-reviewed original studies investigating the neural correlates associated with PPD or fMDD.