Exploring the Reactivity of Electrophilic Organic Carbonates and Thiocarbonates as Vehicles to Convert Hydrosulfide into COS and CS.

J Org Chem

Department of Chemistry and Biochemistry, Materials Science Institute, Knight Campus for Accelerating Scientific Impact, and Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403-1253, United States.

Published: November 2024


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Article Abstract

Hydrogen sulfide (HS) and other reactive sulfur species are important small molecules with biological significance. In addition to common reactive sulfur species like HS, polysulfides, and persulfides, both carbonyl sulfide (COS) and carbon disulfide (CS) have been postulated to be potential sources of reduced sulfur. To better understand this possible connection, we demonstrate that HS can be converted to COS and CS by reaction with simple organic carbonate and thiocarbonate electrophiles, respectively.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11700781PMC
http://dx.doi.org/10.1021/acs.joc.4c01690DOI Listing

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