Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background And Aims: Appropriate continuous reference intervals (RIs) for serum insulin-like growth factor 1 (IGF-1) and insulin-like growth factor-binding protein 3 (IGFBP-3) are important for diagnosing growth hormone deficiency or excess.
Material And Methods: We retrospectively reviewed serum IGF-1 and IGFBP-3 levels in Korean children aged 0-17 years who were diagnosed as healthy during a short stature workup in the outpatient clinics of three hospitals. IGF-1 and IGFBP-3 levels were measured using various immunoassays, including Liaison XL for IGF-1, an immunoradiometric assay (IRMA) for IGFBP-3 (n = 5522), and Immulite 2000 (n = 3036) and cobas e801 (n = 314). We established RIs from the 2.5th to 97.5th percentile RI curves using the lambda-mu-sigma (LMS) method for each sex group.
Results: Pediatric serum continuous IGF-1 and IGFBP-3 reference percentiles by LMS method were found to be immunoassay method-dependent, but aligned relatively well with the manufacturers' RIs. IGFBP-3 levels displayed notable discrepancies among the different immunoassay methods.
Conclusion: Age- and sex-specific pediatric LMS based continuous reference intervals are method dependent and they should be calculated for dynamic parameters that show variations throughout childhood.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11472241 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2024.e38245 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Trends In Reported Outcomes For Growth Hormone Therapy In Children With Growth Hormone Deficiency.
J Clin Endocrinol Metab
September 2025
Developmental Endocrinology Research Group, University of Glasgow, Royal Hospital for Children, Glasgow, UK.
Objective: To understand the frequency and trends in reported outcomes of safety and effectiveness for recombinant human growth hormone (rhGH) therapy for growth hormone deficiency (GHD) in childhood.
Methods: A systematic review was performed in seven English and Chinese language databases. Eligibility criteria included all studies published between 2003 and 2022, with participants who started rhGH before the age of 16 years for GHD.
Correlation between umbilical cord concentration of the growth hormone-IGF axis and small for gestational age: A single-center retrospective, observational study.
Int J Gynaecol Obstet
August 2025
Department of Pediatrics, Chongqing Health Center for Women and Children, Chongqing, China.
Objective: To ascertain the association between small for gestational age (SGA) and growth hormone (GH)-insulin-like growth factor (IGF) system status.
Methods: This retrospective, observational single-center study at a tertiary hospital classified 175 newborns into two groups based on their gestational age and birth weight: SGA (n = 87) or appropriate for gestational age (AGA; n = 88). Umbilical cord blood samples were collected during delivery, and GH, IGF-1, and IGF-binding protein-3 (IGFBP-3) levels were measured using electrochemiluminescence immunoassay, liquid chromatography-tandem mass spectrometry, and chemiluminescence immunoassay, respectively.
Fasting Induces Gene Expression of Insulin-like Growth Factor-binding Proteins in Skeletal Muscles of Chicks.
J Poult Sci
August 2025
Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan.
In mammals, evidence suggests that insulin-like growth factor-binding proteins (IGFBPs) affect skeletal muscle growth in an autocrine and paracrine manner. In the present study, fasting induced significant transcriptional changes in IGFBP genes in the skeletal muscles of layer and broiler chickens. Twelve hours of fasting significantly increased mRNA levels of IGFBP-1 in the biceps femoris (BF; largest skeletal muscle in the thigh) of both chicken types.
View Article and Find Full Text PDFInsulin-like growth factor 1 and insulin-like growth factor-binding protein 3 in central precocious puberty: a systematic review and meta-analysis.
Growth Factors
May 2025
Department of Pediatric General Surgery, Huzhou Maternity & Child Health Care Hospital, Huzhou City, Zhejiang Province, China.
To identify distinct patterns of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein 3 (IGFBP-3) in girls with central precocious puberty (CPP), and to compare IGF-1 and IGFBP-3 levels in patients with CPP and precocious thelarche (PT). A literature search of PubMed, Embase, and Scopus databases was done to identify observational studies. Newcastle-Ottawa Scale (NOS) was used to assess the quality of the studies.
View Article and Find Full Text PDF24-Week jumping exercise influence on growth speed and GH-IGF-1-IGFBP-3 axis among short-stature children.
BMC Pediatr
July 2025
Wuzhi County Hospital of Traditional Chinese Medicine, Wuzhi County, 454950, China.
Objective: To explore the effect of jumping exercises on improving short-stature symptoms and changes of serum GH, IGF-1, IGFBP-3, and IGF-1/IGFBP-3 in short-stature patients, so as to provide potential theoretical reference for short-stature treatment.
Methods: A non-randomized controlled intervention study was registered on January 8, 2025, with the China Clinical Trial Registry (ChiCTR2500095544). This study was conducted with the recruitment of 15 short-stature children in the same environment (Exercise Experimental Group 1); 20 children with normal development level (Blank Control Group 2); and 27 healthy short-stature children in this area (Short Blank Control Group 3).