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Large landslides can involve the multiple failures of regional slopes. To understand the effect of lateral thrust caused by the failure of one slope on its surroundings, the failures of two adjacent highway slopes in Guangdong Province, China, were investigated in detail. The interactive failure processes and landslide morphological characteristics of the two slopes were first analyzed based on the on-site investigation. Then, a plane mechanical model of a large-scale slope was established to evaluate the significant influence of the lateral thrust generated by the west slope acting on the east excavated slope. Furthermore, the extrusion effect of the west slope was modelled under the alternate excavation disturbance and rainfall by transferring the thrust forces onto the interface elements, and the induced failure mechanism and instability mode of the east slope under lateral thrust were reproduced numerically. The results show that the compression-shear failure occurred at the middle and rear slope bodies because of the lateral thrust, which led to the formation of a thrust landslide and the final instability of the east slope.
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http://dx.doi.org/10.1007/s11069-024-06635-9 | DOI Listing |
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Department of Ophthalmology, Barcelona Hospital, Barcelona University, Barcelona, Spain.
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View Article and Find Full Text PDFBioinspir Biomim
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Maritime Engineering Group, Faculty of Engineering and Physical Sciences, University of Southampton, Southampton, United Kingdom.
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View Article and Find Full Text PDFThe CRISPR/Cas12a system has demonstrated extraordinary capabilities in biosensing and molecular diagnostics, owing to its precise recognition and efficient -cleavage ability. However, current crRNA-based Cas12a regulation is relatively crude, requiring costly modifications and multiple components, increasing system complexity. Here, we develop translesion synthesis-driven hierarchical regulation using a template-activator construct for Cas12a activity (THRUST), a powerful and economical Cas12a regulation strategy.
View Article and Find Full Text PDFJ Morphol
June 2025
Faculty of Veterinary Medicine, Aydın Adnan Menderes University, Aydin, Turkey.
The stifle joint is among the most commonly injured joints in dogs. Detailed functional information is required to identify the causes of damage and determine the most appropriate treatment strategy. The lateral condyle of the femur and its attaching structures play an important role in joint stability, which is essential for proper joint movement.
View Article and Find Full Text PDFSci Rep
June 2025
School of Civil Engineering, Guizhou University, Guiyang, 550025, China.
The frequent and complex stress variation of surrounding rock and load transfer of the lining structure during the construction of large-span double-arch tunnels pose certain challenges to subsequent construction control. This study employs a combination of physical model and numerical simulation to investigate the mechanical response of large-span double-arch tunnels during construction, and develops relevant model testing equipment and monitoring systems to provide references for similar tunnel mechanical response studies. The results show that: (1) The displacement and deformation of tunnel structures during construction experience three stages: " Slow deformation → Rapid deformation → Convergence deformation," with the settlement deformation on the same side accounting for over 80% due to construction in the same direction.
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