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Background: Functional constipation (FC) is a common gastrointestinal disorder characterized by abdominal pain and bloating, which can greatly affect the quality of life of patients. Conventional treatments often yield suboptimal results, leading to the exploration of alternative therapeutic approaches.
Aim: To evaluate the efficacy of KiwiBiotic in the management of FC and related symptoms.
Methods: This prospective, interventional, single-center, crossover study compared the safety and effectiveness of KiwiBiotic psyllium husk in managing FC, abdominal pain, and bloating. Participants diagnosed with FC were randomly assigned to receive KiwiBiotic or psyllium husk during the two treatment periods, with a 14-day washout period between them.
Results: Seventy participants were enrolled, 32 of whom received KiwiBiotic followed by psyllium husk, and 33 received KiwiBiotic. KiwiBiotic showed superiority over psyllium husk in alleviating abdominal pain and bloating, as evidenced by significantly lower mean scores. Furthermore, KiwiBiotic resulted in more than 90.0% of patients experiencing relief from various constipation symptoms, while psyllium husk showed comparatively lower efficacy.
Conclusion: KiwiBiotic is an effective treatment option for FC, abdominal pain, and bloating, highlighting its potential as a promising alternative therapy for patients with FC and its associated symptoms.
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http://dx.doi.org/10.4292/wjgpt.v15.i5.97330 | DOI Listing |
Food Chem X
August 2025
Department of Food Science, College of Agriculture and Veterinary Medicine, United Arab Emirates University, Al-Ain 15551, United Arab Emirates.
Plant-based sausages (PBS) were formulated using heat-induced gelation to assess the influence of gluten in terms of structure, texture profile, rheology, digestibility, and shelf-life of PBS. The PBS formulation contained varying amounts of black chickpea flour, mung bean protein isolate, wheat gluten (WG), and fixed amounts of psyllium husk, water, and oil. WG significantly influenced the color.
View Article and Find Full Text PDFMolecules
July 2025
Department of Engineering and Machinery in Food Industry, Faculty of Food Technology, University of Agriculture in Krakow, Balicka 122, 30-149 Krakow, Poland.
The aim of the research was to analyse the effect of different extraction temperatures on the colligative, hydrodynamic, and rheological properties of a water-soluble AXs fractions. The research material consisted of raw water extracts of arabinoxylans obtained from the husk at the following temperatures: 40 °C (AX40), 60 °C (AX60), 80 °C (AX80), and 100 °C (AX100). These were characterised in terms of their hydrodynamic, osmotic, and rheological properties, as well as the average molecular mass of the polysaccharide fractions.
View Article and Find Full Text PDFACS Omega
August 2025
Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Yildiz Technical University, Davutpasa Campus, 34210 Istanbul, Turkey.
This study used PHP (psyllium husk seed powder) and BW (beeswax) to create a hydrogel and Oleogel for bigel production. The resulting bigels were utilized as a fat replacement in cake composition. Bigel manufacturing employed 5 and 10% PHP hydrogels and 7.
View Article and Find Full Text PDFCarbohydr Res
October 2025
K. T. Patil College of Pharmacy, Osmanabad, 413501, MS, India. Electronic address:
Chronomodulated diseases demonstrate circadian fluctuations. Conventional dosage forms are inadequate for mitigating these ailments; instead, time-scheduled drug release is necessary for pharmacological efficacy. The current investigation aims to develop natural, carbohydrate polymer-based novel plug-in capsule, pulsatile drug delivery system with engineered specificity of meloxicam with low aqueous solubility.
View Article and Find Full Text PDFPrz Gastroenterol
July 2024
Department of Nutrition and Dietetics, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
The results of numerous clinical studies available in the literature allow us to conclude that the fiber deserving the name of the gold standard in regulating bowel movements is the psyllium husk obtained from . The physicochemical properties of psyllium, related to its ability to form a gel in an aqueous environment and its ability to retain water in this mucous-gel structure, mean that preparations containing husk show therapeutic effects in both constipation (including occasional and chronic) and diarrhea (acute and chronic). Moreover, the results of studies and clinical experiments indicate that the use of husk in the treatment of bowel disorders is distinguished by significantly higher efficacy compared to pharmacological preparations such as sodium docusate or loperamide.
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