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Objective: First branchial cleft anomalies are rare congenital head and neck lesions. Literature pertaining to classification, work up and surgical treatment of these lesions is limited and, in some instances, contradictory. The goal of this work is to provide refinement of the classification system of these lesions and to provide guidance for clinicians to aid in the comprehensive management of children with first branchial cleft anomalies.
Materials And Methods: Delphi method survey of expert opinion under the direction of the International Pediatric Otolaryngology Group (IPOG) was conducted to generate recommendations for the definition and management of first branchial cleft anomalies. The recommendations are the result of expert consensus and critical review of the literature.
Results: Consensus recommendations include evaluation and diagnostic considerations for children with first branchial cleft anomalies as well as recommendations for surgical management. The current Work classification system was reviewed, and modifications were made to it to provide a more cogent categorization of these lesions.
Conclusion: The mission of the International Pediatric Otolaryngology Group (IPOG) is to develop expertise-based recommendations based on review of the literature for the management of pediatric otolaryngologic disorders. These consensus recommendations are aimed at improving care of children presenting with first branchial cleft anomalies. Here we present a revised classification system based on parotid gland involvement, with a focus on avoiding stratification based on germ layer, in addition to guidelines for management.
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http://dx.doi.org/10.1016/j.ijporl.2024.112095 | DOI Listing |
Front Pediatr
August 2025
Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Acute suppurative thyroiditis (AST) is a rare, potentially life-threatening bacterial infection of the thyroid gland, characterized by rapid progression. We report a rare pediatric case of AST caused by , secondary to a pyriform sinus fistula (PSF), initially misdiagnosed as subacute thyroiditis (SAT). A retrospective analysis highlights the diagnostic challenges and emphasizes the need for early suspicion of PSF in recurrent AST.
View Article and Find Full Text PDFZhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
July 2025
Department of Facial Plastic and Reconstructive Surgery, ENT institute, Eye & ENT Hospital, Fudan University, Shanghai 200031, China Institute of Medical Genetics & Genomics, Fudan University, Shanghai 200032, China.
To determine the diagnosis of microtia-associated syndrome through genetic testing. Peripheral venous blood samples were collected from members of a two-generation family with a syndrome associated with ear malformations (3 patients and 1 normal control). Pathogenic mutations were identified using whole exome sequencing analysis, Sanger sequencing validation, and bioinformatics analysis.
View Article and Find Full Text PDFLaryngoscope
August 2025
The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
Introduction: Branchial cleft cyst carcinomas (BCCC) are rare lateral neck malignancies thought to originate from branchial cleft remnants. Diagnosing primary BCCC should be approached with skepticism; cystic nodal metastasis must be excluded. Due to its rarity, we performed a comprehensive database study to better characterize the ongoing diagnosis of BCCC.
View Article and Find Full Text PDFRadiol Case Rep
October 2025
Department of Radiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Parotid gland agenesis is a rare congenital anomaly with fewer than 30 cases reported in the literature. It can present with xerostomia, facial asymmetry, recurrent infections, or may be entirely asymptomatic. Due to its rarity and potential to mimic other pathological conditions, especially in cases of facial asymmetry, awareness is crucial for accurate diagnosis.
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