Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
HPV-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC) are recognized as distinct entities. There remains uncertainty surrounding the causal effects of smoking and alcohol on the development of these two cancer types. Here we perform multivariable Mendelian randomization (MR) to evaluate the causal effects of smoking and alcohol on the risk of HPV-positive and HPV-negative HNSCC in 3431 cases and 3469 controls. Lifetime smoking exposure, as measured by the Comprehensive Smoking Index (CSI), is associated with increased risk of both HPV-negative HNSCC (OR = 3.03, 95%CI:1.75-5.24, P = 7.00E-05) and HPV-positive HNSCC (OR = 2.73, 95%CI:1.39-5.36, P = 0.003). Drinks Per Week is also linked with increased risk of both HPV-negative HNSCC (OR = 7.72, 95%CI:3.63-16.4, P = 1.00E-07) and HPV-positive HNSCC (OR = 2.66, 95%CI:1.06-6.68, P = 0.038). Smoking and alcohol independently increase the risk of both HPV-positive and HPV-negative HNSCC. These findings have important implications for understanding the modifying risk factors between HNSCC subtypes.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11380676 | PMC |
| http://dx.doi.org/10.1038/s41467-024-51679-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The influence of metabolic dysfunction on depressive symptom trajectories: A one-year follow-up study.
J Affect Disord
September 2025
Département de psychiatrie et d'addictologie, Université de Montréal, Montréal, Québec, Canada; Centre de recherche de l'Institut universitaire en santé mentale (CR-IUSMM), Université de Montréal, Montréal, Québec, Canada.
This study explored the role of metabolic syndrome (MetS) and health-related behaviors in the progression of depressive symptoms over a one-year naturalistic follow-up in patients with depressive disorder. Using data from 153 participants recruited through the Signature Biobank at a psychiatric emergency setting, we tested whether MetS mediated the relationship between health-related behaviors such as smoking, alcohol and drug use, and sleep, and depressive symptom trajectories. Linear mixed models revealed that while depressive symptoms significantly decreased over time, higher MetS score was associated with a slower improvement in depressive symptoms.
View Article and Find Full Text PDFInflammation in Pregnancy: Key Drivers, Signaling Pathways and Associated Complications.
Arch Med Res
September 2025
Departamento de Biología de la Reproducción Dr. Carlos Gual Castro Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México City, Mexico. Electronic address:
In the developmental origins of health and disease (DOHaD) paradigm, there is a clear link between an adverse prenatal environment and the development of non-hereditary diseases later in life. Exposure to intrauterine inflammation, for example, has been associated with several late-onset conditions, including neurological, cardiovascular, immune, and metabolic disorders. Moreover, maternal and fetal health are compromised under exacerbated inflammation, as it can result in spontaneous abortion, preterm delivery, or intrauterine growth restriction.
View Article and Find Full Text PDFPurpose: This study examines the association between neurogenic injury and lumbar intervertebral disc degeneration (LDD) in tethered cord syndrome (TCS) by comparing lumbar sagittal parameters and disc degeneration between patients with normal and abnormal somatosensory evoked potential (SSEP) findings.
Methods: We retrospectively analyzed clinical data from 43 patients diagnosed with TCS between July 2018 and July 2024. Based on tibial nerve somatosensory evoked potential (SSEP) examination results, patients were categorized into SSEP-normal and SSEP-abnormal groups.
Background: Modern lifestyle trends, characterized by sedentary behaviours and poor dietary choices, have a negative impact on the physical and mental health of university students at graduation and post-graduation levels. This study aims to investigate the influence of outdoor activities, dietary habits, psychological wellbeing, physical activities, sleep patterns, and bad habits on the lifestyle of university students in India, with a focus on identifying significant differences in these habits among students and exploring the potential benefits of yoga and naturopathy in improving their overall health.
Methods: An online, survey study was conducted among 710 university students using a self-administered Google Form questionnaire.
Substance use runs in families. Beyond genetic transmission, parental genetics can indirectly influence offspring substance use through the rearing environment, known as "genetic nurture". This study utilized transmitted and non-transmitted polygenic scores to investigate genetic nurture effects on tobacco, alcohol and cannabis use in up to 15,863 adults with at least one genotyped parent from the Lifelines cohort.
View Article and Find Full Text PDF