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http://dx.doi.org/10.1111/pbi.14457 | DOI Listing |
Plant Biotechnol J
December 2024
State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Agriculture, Guangxi Key Laboratory of Sugarcane Biology, Guangxi University, Nanning, China.
Proc Natl Acad Sci U S A
April 2022
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
HIV-1 infection is incurable due to the persistence of the virus in a latent reservoir of resting memory CD4+ T cells. “Shock-and-kill” approaches that seek to induce HIV-1 gene expression, protein production, and subsequent targeting by the host immune system have been unsuccessful due to a lack of effective latency-reversing agents (LRAs) and kill strategies. In an effort to develop reagents that could be used to promote killing of infected cells, we constructed T cell receptor (TCR)-mimic antibodies to HIV-1 peptide-major histocompatibility complexes (pMHC).
View Article and Find Full Text PDFSci Immunol
March 2021
Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Mutations in the oncogenes occur in multiple cancers, and ways to target these mutations has been the subject of intense research for decades. Most of these efforts are focused on conventional small-molecule drugs rather than antibody-based therapies because the RAS proteins are intracellular. Peptides derived from recurrent mutations, G12V and Q61H/L/R, are presented on cancer cells in the context of two common human leukocyte antigen (HLA) alleles, HLA-A3 and HLA-A1, respectively.
View Article and Find Full Text PDFBMC Cancer
June 2020
Department of Gastroenterology, Jing'An District Centre Hospital of Shanghai (Huashan Hospital Fudan University Jing'An Branch), Shanghai, 200040, People's Republic of China.
Background: Stomach cancer (SC) is a type of cancer, which is derived from the stomach mucous membrane. As there are non-specific symptoms or no noticeable symptoms observed at the early stage, newly diagnosed SC cases usually reach an advanced stage and are thus difficult to cure. Therefore, in this study, we aimed to develop an integrated database of SC.
View Article and Find Full Text PDFMAbs
February 2019
a Department of Biotechnology and Life Science, Graduate School of Engineering , Tokyo University of Agriculture and Technology, Tokyo , Japan.
Small bispecific antibodies (bsAbs) are important therapeutic molecules and represent the first bsAb format approved by the United States Food and Drug Administration. Diabody (Db), a small bsAb format, has four possible domain orders; we previously reported the differences in the expression levels and cancer growth inhibition effects upon rearranging the domain order of this format. However, there have been no comprehensive reports on domain rearrangements of bispecific single-chain Db (scDb) and tandem single-chain Fv (taFv), which are widely used bsAb formats.
View Article and Find Full Text PDF