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http://dx.doi.org/10.1093/eurjpc/zwae241 | DOI Listing |
Front Oncol
August 2025
Department of Hematology, General Hospital of the Northern Theater Command, Shenyang, China.
Objective: Chimeric antigen receptor T-cell immunotherapy (CAR-T) is a preferred treatment for relapsed or refractory (R/R) large B-cell lymphoma (LBCL). Several trials have evaluated CD20×CD3 bispecific antibodies (BsAbs) as subsequent therapy in R/R LBCL. This study aimed to investigate the efficacy of CD20×CD3 BsAbs (mosunetuzumab, glofitamab, odronextamab, and epcoritamab) in patients with LBCL who experienced relapse or refractory disease following CAR-T therapy.
View Article and Find Full Text PDFClin Interv Aging
September 2025
Department of Rehabilitation Medicine, Second Campus of Xing 'an League People's Hospital, Wulanhot, Hohhot, Inner Mongolia, People's Republic of China.
Objective: To assess the clinical application and therapeutic efficacy of the Traditional Chinese Medical (TCM) management model among elderly individuals in a sub-health state, and to evaluate its impact on patients' quality of life (QoL).
Methods: A retrospective cohort study was conducted, analyzing clinical data from sub-health elderly patients who received care at a designated medical institution between January 2021 and December 2023. A total of 180 patients meeting the predefined inclusion criteria were recruited and stratified into two arms based on the intervention administered.
Int J Cardiol Heart Vasc
October 2025
Department of Cardiothoracic Surgery, Friedrich-Schiller-University Jena, University Hospital Jena, Germany.
Background: Cardiac biomarkers are important components for diagnosing perioperative myocardial infarction (MI). Efforts to detect MI by biomarker-release only faced heavy criticism, because cardiac biomarker-release has also been observed in situations that are not always related to cell death (e.g.
View Article and Find Full Text PDFNAR Genom Bioinform
September 2025
DNA Repair and Recombination Laboratory, St Vincent's Institute of Medical Research, Fitzroy VIC 3065, Australia.
Meiotic crossovers promote correct chromosome segregation and the shuffling of genetic diversity. However, the measurement of crossovers remains challenging, impeding our ability to decipher the molecular mechanisms that are necessary for their formation and regulation. Here we demonstrate a novel repurposing of the single-nucleus Assay for Transposase Accessible Chromatin with sequencing (snATAC-seq) as a simple and high-throughput method to identify and characterize meiotic crossovers from haploid testis nuclei.
View Article and Find Full Text PDFBackground And Aim: Cancer is currently recognized as one of the leading causes of mortality worldwide. Given the limited understanding of the association between elevated erythrocyte sedimentation rate (ESR) and solid tumors (STs), this study aimed to examine ESR values at the time of malignancy diagnosis.
Methods: This cross-sectional study utilized data extracted from the medical records of cancer patients at Shahid Baghaei-2 Hospital and Shafa Hospital in Ahvaz, Iran, from February 2020 to October 2021.