Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Advanced methodologies, such as hyperthermia and modulation of reactive oxygen species (ROS), exhibit considerable promise in the therapeutic landscape of cancer. These strategies offer a targeted paradigm for combating malignant cells while mitigating damage to healthy tissue. Noteworthy among these approaches is the utilization of superparamagnetic iron oxide nanoparticles, which are renowned for their ability to enhance both hyperthermia and ROS generation specifically within tumor microenvironments. The objective of this investigation is to scrutinize the relationship between the reaction duration and the characteristics of carbon-doped silica core-shell iron oxide nanoparticles (CSIONPs). Specifically, we focus on CSIONP-12, CSIONP-24, and CSIONP-36, synthesized by using varying reaction periods. Through a comprehensive analysis, we primarily evaluate the impact of these formulations on T1 and T2 magnetic resonance imaging (MRI), aiming to elucidate their mechanisms and therapeutic potential in promoting hyperthermia and ROS-mediated cancer therapy. CSIONP-24 emerges as a compelling candidate due to its dual influence on magnetic hyperthermia and ROS generation, suggesting its promise in enhancing cancer treatment outcomes. Furthermore, the findings underscore the exceptional T1-T2 MRI capabilities of this technology, underscoring its versatility and efficacy in the nuanced realm of cancer theranostic.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.langmuir.4c01466 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A cationization strategy to simultaneously enhance reactive oxygen species generation and mitochondria targeting ability for enhanced photodynamic therapy.
J Mater Chem B
September 2025
State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640, China.
Mitochondria-targeted photodynamic therapy (PDT) circumvents the short lifetime and action radius limitation of reactive oxygen species (ROS) and greatly improves the anticancer PDT efficacy. However, current approaches require different molecular engineering strategies to separately improve ROS production and introduce mitochondria targeting ability, which involve tedious synthetic procedures. Herein, we report a facile one-step cationization strategy that simultaneously improves the ROS generation efficiency and introduces mitochondria targeting ability for enhanced PDT.
View Article and Find Full Text PDFA Novel Nanozyme-based Coordination Compound for Synergistic Periprosthetic Joint Infection Treatment and Bone Repair.
Adv Healthc Mater
September 2025
Hebei Key Laboratory of Biomaterials and Smart Theranostics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin, 300131, China.
Periprosthetic joint infection (PJI) represents a serious complication following joint arthroplasty, and it often results in implant failure, prolonged morbidity, and additional healthcare burdens. Current clinical strategies for PJI treatment face obstacles, including antibiotic resistance, high recurrence rate, and compromised bone repair. To address these challenges, a novel nanozyme-based coordination compound designated as W-GA-Van@Zn is developed.
View Article and Find Full Text PDF[Evaluation of the Position Matching Accuracy for Radiological Technologists and Radiation Oncologists in Image-guided Radiation Therapy].
Nihon Hoshasen Gijutsu Gakkai Zasshi
September 2025
Department of Radiation Oncology, Koritsu Tatebayashi Kosei General Hospital.
Purpose: The promotion of task-shifting and task-sharing to facilitate work style reform for physicians has enabled radiological technologists (RTs) to perform primary matching in image-guided radiotherapy. The purpose in this study is to evaluate the position matching accuracy of RTs and radiation oncologist (ROs).
Methods: Position matching was performed by four RTs and two ROs (RO-A and B).
Oxidative stress mediates cardiac electrophysiological injury in inhalation exposure to flavored vaping products.
Heart Rhythm
September 2025
Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, United States. Electronic address:
Background: Electronic nicotine delivery systems (ENDS) utilize "E-liquids" in order to generate "E-vapor", an inhalable aerosolized mixture containing nicotine and flavors. Flavored ENDS are very popular among teens who vape, however, the possible cardiac electrophysiological harm of inhalation exposure to flavored ENDS are not fully understood.
Objective: To test if inhalation exposure to flavoring carbonyls in e-liquids compromises mitochondrial integrity, increases oxidative stress, and leads to cardiac electrophysiological toxicity.
Klotho attenuates D-galactose-induced cardiac aging through the ROS/NLRP3/pyroptosis pathway.
J Mol Cell Cardiol
September 2025
Department of Cardiology, First School of Clinical Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University, 19 Nonglinxia Road, Yuexiu District, Guangzhou 510080, PR China; Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical Uni
Objective: Activation of NLRP3 inflammasome contributes to cardiac aging progression. Klotho, a recognised anti-aging protein, exerts protective effects against cardiac aging. In this study, we aimed to elucidate the protective effects of Klotho on D-galactose (D-gal)-induced cardiac aging and the underlying mechanisms.
View Article and Find Full Text PDF