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http://dx.doi.org/10.1002/jmv.29832 | DOI Listing |
BMC Public Health
August 2025
Institute of Virology, Faculty of Medicine and University Hospital Cologne, Köln, Germany.
Background: Respiratory viral diseases are one of the greatest challenges facing our healthcare system, with them being one of the main causes of death. This has been demonstrated once again by the impact of the SARS-CoV-2 pandemic in recent years. We study the impact of the SARS-CoV-2 pandemic on the prevalence of respiratory viruses by analysing a subset of the Clinical Virology network database, covering 2,216,198 samples tested for 18 different viral pathogens in the time span from 2010 to 2024.
View Article and Find Full Text PDFViruses
July 2025
Interdisciplinary Program of Marine and Fisheries Sciences and Convergent Technology, Pukyong National University, Busan 48513, Republic of Korea.
Microbial infections are an escalating global health threat, driven by the alarming rise of antimicrobial resistance (AMR), which has made many conventional antibiotics increasingly ineffective and threatens to reverse decades of medical progress. The rapid emergence and spread of multidrug-resistant bacteria have severely limited treatment options, resulting in increased morbidity, mortality, and healthcare burden worldwide. In response to these challenges, phage therapy is regaining interest as a promising alternative.
View Article and Find Full Text PDFCell Rep
August 2025
Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584CG Utrecht, the Netherlands. Electronic address:
Since their introduction into humans, H3N2 influenza A viruses have evolved continuously to escape immunity through antigenic drift, driven by mutations in and around the receptor-binding site. Recently, these changes resulted in viruses that recognize elongated glycans, which are less abundant in the human respiratory tract, complicating vaccine strain propagation. This study employed ELISA, glycan arrays, tissue staining, flow cytometry, and hemagglutinin (HA) assays to demonstrate the molecular determinants of recent H3N2 viruses that regained recognition of shorter glycans.
View Article and Find Full Text PDFPLoS Comput Biol
July 2025
Department of Mathematical and Statistical Sciences, University of Alberta, Edmonton, Alberta, Canada.
The COVID-19 pandemic and related non-pharmaceutical interventions (NPIs) significantly alter the transmission dynamics of non-SARS-CoV-2 infectious diseases, with respiratory infections such as influenza being disproportionately affected. We aim to compare influenza's epidemiological characteristics between pre-pandemic and post-pandemic periods to inform public health responses. We develop two influenza transmission models incorporating age structure and multi-strain dynamics, featuring time-varying transmission and mortality rates.
View Article and Find Full Text PDFJ Dairy Sci
September 2025
Ministry of Education Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Key Laboratory of Animal Bacteriology, Ministry of Agriculture, 210095, Nanjing, China. Electronic address:
Klebsiella pneumoniae is an important pathogen causing bovine mastitis and milk contamination, with severe consequences for the dairy industry. Due to increasing bacterial antibiotic resistance, phage therapy has regained attention; however, studies on the antibacterial properties of Klebsiella phages in milk are limited. We evaluated the antibacterial efficacy of the K5-specific phage in milk at 4°C and 38°C with different multiplicities of infection (MOI = 10, 1, and 0.
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