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Two major etiologies of hyperbilirubinemia include hemolysis and cholestasis. Although rare, the former can give rise to the latter through the formation of pigment gallstones and subsequent biliary tree obstruction. We report a case of a 57-year-old woman with systemic lupus erythematosus who presented with dyspnea and right upper quadrant abdominal pain. She was found to have hepatolithiasis and choledocholithiasis secondary to warm autoimmune hemolytic anemia in the setting of COVID-19. In patients with symptomatic anemia secondary to acute hemolysis and concomitant right upper quadrant abdominal pain, elevated hepatocellular laboratory results should prompt a high clinical suspicion for biliary tree pigment stones.
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http://dx.doi.org/10.14309/crj.0000000000001434 | DOI Listing |
Infect Agent Cancer
July 2025
Department of Biliary-Pancreatical Surgery, General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, Heilongjiang Province, China.
Background: The cause and carcinogenesis of cholangiocarcinoma (CCA) remain unclear. In this study, we conducted a population-based case-control study in China to evaluate the effects of diabetes mellitus (DM), hepatitis B virus (HBV) infection, and other potential risk factors for cholangiocarcinoma (CCA).
Methods: A hospital-based, case-control study was conducted, including 245 CCA patients (168 with extrahepatic cholangiocarcinoma (eCCA) and 77 with intrahepatic cholangiocarcinoma (iCCA), diagnosed at The Second Affiliated Hospital of Harbin Medical University in China between January 2019 and June 2024, along with 490 healthy controls matched in a 2:1 ratio.
Zhonghua Wai Ke Za Zhi
June 2025
Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310020, China.
To summarize the initial experience of 5G-ultra-long-distance robotic hepatectomy. This is a retrospective case series study. The clinical information from 5 cases of 5G ultra-long-distance robot-assisted hepatectomy performed was collected from June 2023 to October 2024, in collaboration between Sir Run Run Shaw Hospital, Zhejiang University School of Medicine in Hangzhou and Alaer Hospital, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine in Alaer, located 4 600 km apart.
View Article and Find Full Text PDFHPB (Oxford)
February 2025
Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Viet Nam.
Front Med (Lausanne)
November 2024
Center of Hepatobiliary Pancreatic Disease, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Background: Hepatolithiasis is regarded as the presence of stones in the intrahepatic bile ducts. Recurrent inflammation of bile ducts can bring many bad effects. How to completely remove stones is still a challenge.
View Article and Find Full Text PDFInfect Disord Drug Targets
May 2025
ITM University Gwalior, (M.P.), India.
This review explores various biliary tract diseases caused by different organisms, including cholelithiasis, hepatolithiasis, and choledocholithiasis. The biliary tract's primary functions include collecting, storing, concentrating, and delivering bile juice produced by the liver. Neurohormonal systems involving the vagus and splanchnic nerves, alongside cholecystokinin, regulate gallbladder movement during fasting and digestion.
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