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http://dx.doi.org/10.1016/j.jacadv.2024.100865 | DOI Listing |
Sci China Life Sci
September 2025
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
The rapid repair of intraoral mucosal injuries is crucial for restoring oral epithelial homeostasis. Alpha-ketoglutarate (αKG), a multi-potential metabolite involved in protein synthesis, epigenetic regulation, and immune response, holds the potential in tissue homeostasis and wound repair. Here, we report that administration of αKG accelerates palatal wound healing, with enhanced re-epithelialization and increased collagen deposition.
View Article and Find Full Text PDFNPJ Metab Health Dis
September 2025
ATLAS Molecular Pharma, Parque Tecnológico de Bizkaia, Ed. 800, 48160, Derio, Spain.
Molecular aging clocks estimate biological age from molecular biomarkers and often outperform chronological age in predicting health outcomes. Types include epigenetic, transcriptomic, proteomic, and metabolomic clocks. NMR-based metabolomic clocks provide a non-invasive, high-throughput platform to assess metabolic health.
View Article and Find Full Text PDFUrol Oncol
September 2025
Department of Urology, University of Washington, Seattle, WA; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA.
Introduction And Objectives: Transurethral Resection of Bladder Tumor (TURBT) is a diagnostic staging procedure for bladder cancer (BC). Its pathologic interpretation may be limited by cautery artifact, lack of spatial orientation of tumor specimens, inter-pathologist variance in identifying subtypes, and sampling bias. Accurately identifying subtype histology (SH) on TURBT is critical for clinical decisions.
View Article and Find Full Text PDFAgeing Res Rev
September 2025
College of Health and Life Sciences, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar; College of Science and Engineering, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar. Electronic address:
Several strategies have emerged lately in response to the rapid increase in the aging population to enhance health and life span and manage aging challenges. Developing such strategies is imperative and requires an assessment of biological aging. Several aging clocks have recently been developed to measure biological aging and to assess the efficacy of longevity interventions.
View Article and Find Full Text PDFAging Dis
August 2025
Institute of Parasitology and Biomedicine López-Neyra, CSIC, Granada, Spain.
Giant cell arteritis (GCA) is a complex inflammatory disease affecting individuals over 50 suggesting a strong link with aging-related immune and vascular changes. However, the precise mechanisms underlying this age-related susceptibility remain poorly understood. Considering the relevance of aging in GCA, genetic factors influencing biological aging markers, such as telomere shortening and epigenetic age acceleration (EAA), might also contribute to its development.
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