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http://dx.doi.org/10.1002/ctm2.1676 | DOI Listing |
NAR Mol Med
July 2025
Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada.
Advanced maternal age increases the risk of pregnancy complications due, in part, to changes in the uterine environment. Here, we show that uterine aging in mice is associated with a progressive increase in transcriptional variation, accompanied by a notable accumulation of activating histone marks at multiple genomic loci. Importantly, the transcriptional signatures of uterine aging differ substantially from senescence markers associated with organismal aging.
View Article and Find Full Text PDFFASEB J
September 2025
Department of Hematology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China.
Epilepsy is a common chronic nervous system disease that threatens human health. However, the role of FOXC1 and its relations with pyroptosis have not been fully studied in epilepsy. Sprague-Dawley rats were obtained for constructing temporal lobe epilepsy (TLE) models.
View Article and Find Full Text PDFExp Cell Res
August 2025
Pharmaceutical Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmacodynamics and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:
Bone is a remarkable dynamic tissue, continually undergoing intricate processes of development, repair, and lifelong remodeling, all vital for maintaining skeletal integrity, facilitating injury recovery, and preserving overall health. Mesenchymal stem cells (MSCs) are central to these processes, characterized by their self-renewal capacity, multipotent differentiation (including osteoblasts), and crucial roles in secreting growth factors and remodeling the extracellular matrix. The highly conserved transcription factors FOXC1 and FOXC2 are crucial for correct skeletal development, profoundly influencing both intramembranous and endochondral ossification.
View Article and Find Full Text PDFPak J Pharm Sci
August 2025
Department of Ophthalmology, The Affiliated People's Hospital of Ningbo University, Ningbo 315040, School of Basic Medical Science, School of Medicine, Ningbo University, Ningbo, Zhejiang, China.
The objective of this study is to investigate the shared genes that are differentially expressed (DEGs) between CES and T2DM, as well as uncover the hidden molecular mechanisms involved. We retrieved the gene expression profiles for CES (GSE58294) and T2DM (GSE25724) from Gene Expression Omnibus (GEO) database. We then per formed 5 analyses: Identify the overlapping DEGs between CES and T2DM, correlation analysis of hub genes; transcriptional regulation analysis of hub genes; single-cell sequencing analysis and potential therapeutic drug prediction.
View Article and Find Full Text PDFbioRxiv
July 2025
Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Biomedicum, Karolinska Institutet, 17177 Stockholm, Sweden.
The vertebrate central nervous system is enveloped by the meninges, consisting of the pia, arachnoid, and dura layers. The arachnoid is hypothesised to give rise to the most common primary intracranial tumours, meningiomas. However, molecular evidence supporting this hypothesis is lacking.
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