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The inaugural total laryngectomy in history was conducted by Billroth in 1873. Nevertheless, significant enhancements to the technique were achieved through the contributions of Gluck, Sorensen, and various other surgeons. Throughout the twentieth century, advancements in anesthesia, infectious disease, hospital hygiene, antibiotic therapy, resuscitation, and the expertise of numerous laryngologists elevated total laryngectomy to a pivotal surgical intervention in head and neck surgery. The latter half of the twentieth century witnessed a paradigm shift with the emergence of organ preservation protocols. Total laryngectomy became the preferred choice for patients experiencing radiotherapy failure. However, the widespread use of laryngeal conservative treatments appears to be correlated with a decline in overall survival rates in the United States and Europe. The evolution of new minimally invasive surgical approaches in the twenty-first century may usher in a revolutionary era in the management of laryngeal carcinoma, offering the potential for improved survival and functional outcomes.
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http://dx.doi.org/10.3389/fonc.2024.1351549 | DOI Listing |
Pain Manag
September 2025
Anesthesia and Surgical Intensive Care, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Introduction: The cervical plexus block (CPB) delivers analgesia for surgeries in the head and neck . Patient-controlled analgesia (PCA) has been utilized to enhance pain management. This study evaluates combined bilateral superficial and deep CPB versus PCA in postoperative pain management after total laryngectomy.
View Article and Find Full Text PDFFront Oncol
August 2025
Department of Otolaryngology-Head and Neck Surgery, CHUV, University of Lausanne, Lausanne, Switzerland.
Total laryngectomy, a surgical procedure involving the complete removal of the larynx, has been a crucial treatment for advanced laryngeal cancer since its introduction in 1873. Over the past 150 years, this procedure has evolved significantly, with improvements in surgical techniques, postoperative care, and rehabilitation methods leading to better survival rates and quality of life for patients. While organ-preserving approaches like radiochemotherapy have gained prominence in recent decades, total laryngectomy remains an essential option for cases of advanced cancer or when other treatments fail.
View Article and Find Full Text PDFMicrosurgery
September 2025
Department of Otorhinolaryngology - Head and Neck Surgery, Cantonal Hospital Lucerne, Lucerne, Switzerland.
Objective: Reconstruction after partial laryngectomy poses challenges in preserving voice, swallowing, and airway patency. Tailored laryngeal free-flap reconstructions using multiple chimeric perforator flaps aim to maximize functional preservation of the larynx and facilitate swallowing rehabilitation by enhancing larynx mobility.
Methods: Various compartmental laryngeal reconstructions using chimeric free flaps were performed on seven male patients (aged 40-82) with laryngeal malignancies following open partial laryngectomy.
Clin Otolaryngol
September 2025
Faculty of Health Sciences, Joyce & Irving Goldman Medical School at Ben Gurion University of the Negev, Beersheba, Israel.
Objective: To evaluate the prognostic significance of preoperative inflammatory markers including platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR) and albumin-to-globulin ratio (AGR) in patients with laryngeal squamous cell carcinoma (LSCC) undergoing total laryngectomy (TL).
Methods: Patients were stratified by preoperative inflammatory markers: NLR > 3, PLR > 109.54, and AGR < 1.
J Laryngol Otol
September 2025
Department of Otorhinolaryngology Head and Neck Surgery, Guy's and St Thomas' NHS Trust, London, UK.