Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Animal models of fatal pneumonia caused by () have not been reliably generated using many strains of less virulent serotypes. Pulmonary infection of a less virulent serotype1 strain in the immunocompetent mice was established via the intratracheal aerosolization (ITA) route. The survival, local and systemic bacterial spread, pathological changes and inflammatory responses of this model were compared with those of mice challenged via the intratracheal instillation, intranasal instillation and intraperitoneal injection routes. ITA and intratracheal instillation both induced fatal pneumonia; however, ITA resulted in better lung bacterial deposition and distribution, pathological homogeneity and delivery efficiency. ITA is an optimal route for developing animal models of severe pulmonary infections.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11323861 | PMC |
| http://dx.doi.org/10.1080/17460913.2024.2355738 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mapping the infectious burden in VEXAS syndrome: a systematic review and rationale for prevention.
Lancet Rheumatol
September 2025
Service de Médecine interne et polyvalente, Centre Hospitalier du Haut-Anjou, Château-Gontier, France; Université d'Angers, Inserm, CNRS, MITOVASC, Equipe MitoLab, SFR ICAT, F-49000 Angers, France. Electronic address:
Infections are increasingly recognised as a major cause of morbidity and mortality in patients with vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome. We conducted a systematic review to characterise the infectious burden of VEXAS syndrome and propose preventive strategies. We included 57 studies (813 patients) showing that infections in patients with VEXAS syndrome were frequent, severe in 40-60% of cases, and fatal in 6-15% of cases.
View Article and Find Full Text PDFIncidence, etiologies, and outcomes of severe pediatric community-acquired empyema before and after the pandemic: an Italian multicentric study.
Eur J Pediatr
September 2025
Pediatric Infectious Diseases, Pediatric Emergency Care and Pediatric Ultrasound Department of Woman and Child Health and Public Health and Fondazione, Policlinico Universitario "A. Gemelli," , Rome, Italy.
Unlabelled: An increase in severe and invasive infections has been reported since the COVID-19 pandemic. However, most evidence comes from monocentric studies without nationwide representativeness. This multicenter, nationwide, retrospective study, conducted within the network of the Italian Society of Pediatric Infectious Diseases (SITIP), aimed to compare the severity of empyema at presentation in children (aged 1 month to 18 years) admitted to 19 Italian hospitals before, during, and after the pandemic.
View Article and Find Full Text PDFFatal Trichosporon asahii Fungemia Following Polymicrobial Bacteremia in a Non-neutropenic Elderly Patient: A Case Report.
Cureus
August 2025
Medical Mycology Research Center, Chiba University, Chiba, JPN.
species are known to cause disseminated infections in immunocompromised hosts, typically in patients with hematological malignancies undergoing chemotherapy and those with a history of antifungal use. This case report described a non-neutropenic 85-year-old male patient with fungemia following polymicrobial bacteremia. He presented with fever and disturbed consciousness and was admitted for sepsis (day 1).
View Article and Find Full Text PDFThe treatment of amphotericin B-resistant C neoformans meningitis: A case report and literature review.
Medicine (Baltimore)
August 2025
Department of Orthopedics, Xiangtan Central Hospital, Xiangtan, Hunan Province, China.
Rationale: Cryptococcal meningitis is caused by Cryptococcus neoformans and Cryptococcus gattii, predominantly affects immunocompromised host. Resistance to amphotericin B poses therapeutic challenges, especially in immunocompetent individuals, where evidence is scarce.
Patient Concerns: This study reports a case of an old immunocompetent male diagnosed with amphotericin B-resistant C neoformans meningitis.
Investigating factors influencing injury severity in crashes involving vulnerable road users in Pakistan.
Sci Rep
September 2025
Center of Excellence in Trauma and Accidents, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.
Road traffic crashes claim around 1.19 million lives annually worldwide, with over half of the fatalities involving vulnerable road users (VRUs). While several studies have explored the risk factors associated with specific categories of VRUs in Pakistan, research focusing on VRUs collectively, considering all categories and their unique safety challenges, remains limited.
View Article and Find Full Text PDF