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Article Abstract
Most fine ambient particulate matter (PM)-based epidemiological models use globalized concentration-response (CR) functions assuming that the toxicity of PM is solely mass-dependent without considering its chemical composition. Although oxidative potential (OP) has emerged as an alternate metric of PM toxicity, the association between PM mass and OP on a large spatial extent has not been investigated. In this study, we evaluate this relationship using 385 PM samples collected from 14 different sites across 4 different continents and using 5 different OP (and cytotoxicity) endpoints. Our results show that the relationship between PM mass vs. OP (and cytotoxicity) is largely non-linear due to significant differences in the intrinsic toxicity, resulting from a spatially heterogeneous chemical composition of PM. These results emphasize the need to develop localized CR functions incorporating other measures of PM properties (e.g., OP) to better predict the PM-attributed health burdens.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11187120 | PMC |
| http://dx.doi.org/10.1038/s41467-024-49649-4 | DOI Listing |
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