Delivery mode impacts gut bacteriophage colonization during infancy.

Cesarean section delivery is associated with altered early-life bacterial colonization and later adverse inflammatory outcomes. Although gut bacteriophages can alter the gut microbiome and host responses, little is known about how delivery mode impacts bacteriophage colonization over time. Therefore, we conducted shotgun metagenomic sequencing on serial stool samples from infants from birth to 24 months of age.

Microbiome in Neuroblastoma: A Virgin Island in the World of Onco-Microbiome.

The composition of the gut and/or tumor microbiome has been intricately involved in the onset of carcinogenesis, tumor progression, therapy response, and patient outcomes in diverse solid cancers. The microbiome type, composition, and their metabolome have been functionally implicated in the multifarious cellular processes, transformation, proliferation, tumor immune evasion, cellular migration, etc. Despite such compelling evidence on the role of microbiome interactions in cancer, the realization of their role in neuroblastoma (NB), the deadly extracranial tumor in infants is few and fragmentary.

Ten-Year Comparison of Fungicide Sensitivity and Mycotoxin Production of Fusarium Head Blight Isolates from Korea.

Fusarium head blight (FHB) is an important disease reducing yield and quality of wheat and barley. To study changes in fungicide efficacy over time, 161 FHB isolates (F. asiaticum and F.

A DEL-1/αvβ3 integrin axis promotes brown adipocyte progenitor proliferation and cold-induced brown adipose tissue adaptation.

Objectives: Cold-triggered adaptation of the brown adipose tissue (BAT) promotes increased non-shivering thermogenesis and helps maintain body temperature. This study investigated the role of the secreted protein developmental endothelial locus-1 (DEL-1) in regulating BAT adaptation to cold.

Methods: DEL-1 expression in BAT was assessed following cold exposure in mice.