Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Parkinson's disease (PD) is a chronic neurodegenerative disease associated with a progressive loss of dopaminergic neurons, clinically characterized by motor and non-motor signs. Frailty is a clinical condition of increased vulnerability and negative health outcomes due to the loss of multiple physiological reserves. Chronic hyperglycemia and insulin resistance, which characterize diabetes mellitus (DM), have been reported to alter dopaminergic activity, increase the risk of PD, and influence the development of frailty. Even though diabetes may facilitate the development of frailty in patients with PD, this relationship is not established and a revision of the current knowledge is necessary. Furthermore, the synergy between DM, PD, and frailty may drive clinical complexity, worse outcomes, and under-representation of these populations in the research. In this review, we aimed to discuss the role of diabetes in the development of frailty among patients with PD. We summarized the clinical characteristics and outcomes of patients with concomitant DM, PD, and frailty. Finally, interventions to prevent frailty in this population are discussed.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11177766 | PMC |
| http://dx.doi.org/10.3389/fmed.2024.1377975 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of preoperative beta-hydroxy-beta-methylbutyrate, arginine, and glutamine supplementation on inflammation in patients with cardiac surgery: A secondary analysis of a randomized controlled trial.
J Cardiol
September 2025
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Hyogo, Japan.
Background: Preoperative physical frailty is a significant predictor of adverse postoperative outcomes in older patients undergoing cardiac surgery. Inflammation plays a crucial role in the development of frailty and contributes to postoperative complications. This study investigated the effects of preoperative beta-hydroxy-beta-methylbutyrate (HMB), arginine, and glutamine supplementation on inflammatory markers, nutritional status, and renal function in older patients undergoing cardiac surgery.
View Article and Find Full Text PDFAn Electronic Health Record-Wide Association Study to identify populations at increased risk of E. coli bloodstream infections.
J Infect
September 2025
Nuffield Department of Medicine, University of Oxford, Oxford, UK; The National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance at the University of Oxford, Oxford, UK; The National Institute for Health Research Oxford Bi
Objectives: Escherichia coli bacteraemias have been under mandatory surveillance in the UK for fifteen years, but cases continue to rise. Systematic searches of all features present within electronic healthcare records (EHRs), described here as an EHR-wide association study (EHR-WAS), could potentially identify under-appreciated factors that could be targeted to reduce infections.
Methods: We used data from Oxfordshire, UK, and an EHR-WAS method developed for use with large-scale COVID-19 data to estimate associations between E.
Unlabelled: The childhood poor in wealthy countries have reported worse cognitive, muscle and mental functions as well as more frailty and multimorbidity as older adults. But it is uncertain whether the childhood poor around the world fall short of attaining healthy ageing because information of childhood conditions is often erroneous. Here I present new evidence on the life course shaping of healthy ageing among older adults around the world.
View Article and Find Full Text PDFPredictors of health-related quality of life in older adults over a course of twelve years - Results from a large population-based study using a machine learning approach.
Int Psychogeriatr
September 2025
Department of General Internal Medicine and Psychosomatics, Heidelberg University Hospital, Heidelberg, Germany. Electronic address:
Background: The proportion of older people is growing dramatically, implying that predictors of health-related quality of life (HRQoL) in older adults are of major interest within public health research.
Methods: Analyses were based on the ESTHER study, a German population-based cohort study conducted in the federal state of Saarland, Germany. The study was initiated in 2000-2002 and included 9940 community-dwelling older adults recruited via general practioners.
Cognitive frailty and cardiometabolic risk in middle-aged and older adults: evidence from the UK and China.
Aging Clin Exp Res
September 2025
School of Population Health, Faculty of Health Sciences, Curtin University, Perth, Western Australia, Australia.
Background: Cognitive frailty, a novel construct integrating cognitive and physical deficits, is increasingly recognized in aging research.
Aims: This study aimed to examine the associations between cognitive frailty and cardiometabolic risk in two nationally representative cohorts from China and the United Kingdom.
Methods: We analyzed data from 7,628 participants in the China Health and Retirement Longitudinal Study (CHARLS) and 4,703 participants from the English Longitudinal Study of Ageing (ELSA), all aged ≥ 50 years.