Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Purpose: Trimethylamine-N-oxide (TMAO) is a gut-derived metabolite associated with cardiovascular disease (CVD). In preclinical and observational studies, resveratrol and exercise training have been suggested as potential strategies to reduce the systemic levels of TMAO. However, evidence from experimental studies in humans remains unknown. This project examined the dose-dependent effects of a combined resveratrol intervention with exercise training on circulating TMAO and other related metabolite signatures in older adults with high CVD risk.
Methods: Forty-one older adults [mean (±SD) age of 72.1 (6.8) years] participated in a 12-week supervised center-based, multi-component exercise training intervention [2×/week; 80 min/session] and were randomized to one of two resveratrol dosages [Low: 500 vs. High:1000 mg/day] or a cellulose-based placebo. Serum/plasma were collected at baseline and post-intervention and evaluated for TMAO and associated analytes.
Results: After the 12-week intervention, TMAO concentration increased over time, regardless of treatment [mean (±SD) Placebo: 11262 (±3970); Low:13252 (±1193); High: 12661(±3359) AUC; p = 0.04]. Each resveratrol dose produced different changes in metabolite signatures. Low dose resveratrol upregulated metabolites associated with bile acids biosynthesis (i.e., glycochenodeoxycholic acid, glycoursodeoxycholic acid, and glycocholic acid). High dose resveratrol modulated metabolites enriched for glycolysis, and pyruvate, propanoate, β-alanine, and tryptophan metabolism. Different communities tightly correlated to TMAO and resveratrol metabolites were associated with the lipid and vascular inflammatory clinical markers [|r| > 0.4, p < 0.05].
Conclusion: These findings suggest a distinct dose-dependent adaptation response to resveratrol supplementation on circulating metabolite signatures but not on TMAO among high-risk CVD older adults when combined with an exercise training intervention.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.exger.2024.112479 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Physical Activity and Exercise Patterns of Submariners in Land and Sea Environments.
Mil Med
September 2025
School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA 6027, Australia.
Introduction: Submarine environments pose unique challenges to maintaining physical activity and exercise routines due to confined spaces, demanding schedules, and limited resources. This study investigated submariners' physical activity patterns, sleep quality, and perceived exercise barriers in both land- and sea-based settings, with the goal of informing targeted health interventions.
Materials And Methods: Ethics approval was granted by the Defence Science and Technology Group and Edith Cowan University review panels.
Valid measures of cognitive assessment with Aboriginal and Torres Strait Islander peoples are urgently needed: construct and concurrent validity of the Perceive, Recall, Plan and Perform Assessment (PRPP-A).
Disabil Rehabil
September 2025
Occupational Performance Network, Sydney, Australia.
Purpose: Initial studies identified the Perceive, Recall, Plan and Perform Assessment (PRPP-A) as a cognitive assessment with potential for culturally safe use with Aboriginal and Torres Strait Islander peoples with neurocognitive impairments in the Northern Territory of Australia. This study examines construct and concurrent validity of the PRPP-A.
Methods: Data were collected from a medical record review.
Critical Assessment of the Recommended Alert Limit Curves for Occupational Heat Exposure.
Am J Ind Med
September 2025
Department of Kinesiology, Indiana University School of Public Health, Bloomington, Indiana, USA.
Background: Occupational heat stress recommendations aim to achieve thermal equilibrium and keep core temperature (T) below 38.0°C. We assessed the recommended alert limit curves when: (1) work-rest ratios are adjusted based on wet-bulb globe temperature (WBGT) at a fixed rate of metabolic heat production (H) and (2) H is adjusted based on WBGT at a fixed work-rest ratio.
View Article and Find Full Text PDFVirtual reality-enhanced exergames for weight control: a systematic review and meta-analysis of randomized controlled trials.
Int J Obes (Lond)
September 2025
Mater Hospital, Brisbane, QLD, Australia.
Background: Obesity is an important public health issue. Virtual reality provides an opportunity to increase benefits of traditional exercise programs with more immersive, interactive, and enjoyable experiences for weight control.
Objectives: This study aimed to explore the efficacy of virtual reality-enhanced exergames for obesity-related outcomes, including body weight, body mass index, body fat, and waist circumference.
A Randomized Trial of Cervical Stabilization Exercise Training Via Telerehabilitation for Migraine.
Pain Manag Nurs
September 2025
Ankara Yıldırım Beyazıt University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Ankara, Turkey.
Purpose: To compare the effects of cervical stabilization exercise training via telerehabilitation (CSET-T) in addition to standard treatment on pain, forward head posture, cervical mobility, muscle performance, functional status, sleep quality, and quality of life in individuals with migraine in comparison to the standard treatment alone.
Methods: The control group (n = 20) received standard treatment alone (medication+recommendations). The stabilization group (n = 20) was given CSET-T in addition to standard treatment 3 days a week for 8 weeks.