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Objectives: Access to evidence-based self-management support in pediatric inflammatory bowel disease (IBD) is a significant challenge. Digital therapeutic solutions can increase access and provide data to patients and providers that would otherwise not be available. We have iteratively developed a mobile application, Self-Management Assistance with Recommended Treatment (SMART) IBD, that allows patients to access self-management support and record symptoms and medication adherence.
Methods: We conducted a pilot and feasibility study for this digital therapeutic tool in which patients used SMART IBD for 30 days.
Results: Results indicated that patients rated the app quality as good and accessed the app adequately overall, with some pages being used often. Medication adherence increased over the course of the study and was associated with sleep duration, mood, and stool consistency and blood content.
Conclusions: Overall, this study demonstrated adequate feasibility for the SMART IBD app and initial findings suggest that additional research is needed to explore the potential impact of this tool in clinical care.
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http://dx.doi.org/10.1002/jpn3.12229 | DOI Listing |
Am J Bot
September 2025
Key Laboratory of Biodiversity and Environment on the Qinghai-Tibetan Plateau, Ministry of Education, School of Ecology and Environment, Xizang University, Lhasa, China.
Premise: The demographic histories of temperate plants in Northeast Asia in response to Quaternary climate oscillations have long been the focus of evolutionary biologists, but have rarely been studied in herbaceous plants. Here, we investigated the phylogeographic patterns of Mukdenia and Oresitrophe.
Methods: We sequenced two plastid regions for O.
RSC Adv
July 2025
Nursing Department, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Hangzhou 310000 Zhejiang China
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), remains a challenging chronic disorder with complex pathophysiology and limited therapeutic options. Peptide-based therapeutics have emerged as promising alternatives, offering high specificity, favorable safety profiles, and unique biological activities compared to traditional treatments. However, challenges including enzymatic degradation, poor oral bioavailability, and instability hinder their clinical translation.
View Article and Find Full Text PDFClin Gastroenterol Hepatol
June 2025
Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Electronic address:
Background & Aims: Use of wearable technologies is increasing and may offer potential benefits in collecting actionable health data. We performed a scoping review on the use of wearable technologies in patients with inflammatory bowel disease (IBD).
Methods: The PubMed, Embase, and Scopus databases were searched until February 7, 2025, and original studies on the use of wearables in IBD were included.
J Colloid Interface Sci
December 2025
School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, PR China. Electronic address:
Inflammatory bowel disease (IBD), a chronic inflammatory gastrointestinal disease, is closely related to diverse inflammatory factors like reactive oxygen and nitrogen species (RONS) and cell-free DNA (cfDNA). Herein, tannic acid (TA) modified hafnium hydride nanosheets (HfH@TA NSs) with a thickness of 1-4 nm, prepared by liquid-phase exfoliation, were explored as a high-performance anti-inflammatory agent for IBD treatment. By virtue of the high specific surface area of two-dimensional structure, HfH@TA NSs can effectively not only scavenge RONS, but also eliminate cfDNA, thus inhibiting the pro-inflammatory responses.
View Article and Find Full Text PDFPeerJ
June 2025
School of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.
Background: Inflammatory bowel disease (IBD) is characterized by chronic inflammation. Ulcerative colitis (UC) is a subtype of IBD. The symptoms of UC include inflammation, damage to crypts, and ulceration.
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