Publications by authors named "Anuraag Jena"

Inflammatory Bowel Disease (IBD) is increasing in incidence globally, with low- and middle-income countries (LMICs) facing a rapid surge in disease burden. However, the availability of structured training programs for IBD care remains highly unequal. This review evaluates the current global landscape of IBD workforce training, with an emphasis on identifying gaps and proposing solutions to enhance multidisciplinary preparedness.

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Background: The radiological features of Crohn's disease (CD)-associated and cryptoglandular perianal fistulae (PAF) are similar, but distinguishing them is crucial for treatment decisions. Delayed CD diagnosis in PAF can worsen long-term outcomes and accurate radiological differentiation may help identify CD-associated PAF.

Methods: In a retrospective single-center study, we analyzed the pelvic MRI images of the patients with PAF.

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Background: The incidence and prevalence of inflammatory bowel disease [IBD] have increased significantly in low- and middle-income countries [LMICs] in recent decades. Managing IBD in these settings presents substantial challenges. This consensus aims to describe the epidemiology of IBD in LMICs and to highlight the key challenges in its diagnosis and treatment.

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Background & Aims: Use of wearable technologies is increasing and may offer potential benefits in collecting actionable health data. We performed a scoping review on the use of wearable technologies in patients with inflammatory bowel disease (IBD).

Methods: The PubMed, Embase, and Scopus databases were searched until February 7, 2025, and original studies on the use of wearables in IBD were included.

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Background And Study Aims: Esophageal variceal bleeding is affected by various risk factors. We hypothesized that increased exposure to gastric acid in patients with abnormal gastroesophageal flap valve (GEFV) might increase esophageal variceal bleeding. The aim of this study is to investigate the relationship between GEFV and esophageal variceal bleeding episodes.

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Inflammatory bowel disease (IBD) is rising at an alarming rate in south Asia and there is a paucity of data on IBD in this region. For this scoping review, we conducted a systematic search to identify all observational and interventional studies on IBD in south Asia. Of 14 924 potentially eligible studies, 524 were included in this scoping review and summarised under the domains of epidemiology, natural history, phenotype and comorbid conditions, therapeutics, and psychosocial health.

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Background/aims: Inflammatory bowel disease (IBD) is increasing across the globe, more so in populous countries like India. We aimed to study the disease burden and epidemiological trends of IBD in India and look closer into the disease pattern across the country from 1990 to 2019.

Methods: The burden of IBD was estimated in India using the data from the Global Burden of Disease estimate for 2019, which is a comprehensive worldwide project.

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Article Synopsis
  • * Out of 82 patients, a significant number did not respond to steroid treatment, but the baseline histological scores did not show a strong association with the need for second-line therapy or colectomy.
  • * The conclusion suggests that these histological scores are not reliable predictors for treatment needs in ASUC, prompting a call for further research on their long-term impact.
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Background: The gastrointestinal symptom rating scale (GSRS) is a questionnaire in English language which is designed to assess the clinical symptoms in patients with irritable bowel syndrome (IBS) and peptic ulcer disease. This validated scale has questions on around 15 items and has been validated in patients with dyspepsia and IBS.

Aim: To translate and validate the English version of the GSRS questionnaire to the Hindi version.

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Background: Dietary knowledge, perception and practices may have a role in determining the nutritional status of patients with inflammatory bowel disease (IBD). However, the assessment of these patterns has infrequently been done in developing countries. We aimed to evaluate patients with ulcerative colitis (UC) about their dietary beliefs, practices and changes after the diagnosis.

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Background: Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the treatment of choice for medically refractory inflammatory bowel disease (IBD). In this systematic review and meta-analysis, we assess outcomes and safety of endoscopic balloon dilatation (EBD) for IPAA strictures.

Methods: A systematic search of numerous databases was performed through June 2023 to identify studies reporting on the outcomes of EBD in pouch-related strictures.

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Background And Aims: Colonoscopy has a vital role in the diagnosis of inflammatory bowel disease (IBD), as well as in the estimation of disease severity, monitoring response to therapy, and surveillance for neoplasia. We performed a systematic review of randomised trials of various bowel preparations for colonoscopy in IBD.

Methods: We searched various electronic databases (PubMed, Embase, and CENTRAL) for studies reporting about the use of various strategies to improve colonoscopy preparation in IBD.

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Background/aims: Patients of ulcerative colitis (UC) on follow-up are routinely evaluated by sigmoidoscopy. There is no prospective literature to support this practice. We assessed agreement between sigmoidoscopy and colonoscopy prospectively in patients with disease extent beyond the sigmoid colon.

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Article Synopsis
  • Recent use of larger metal stents for walled-off necrosis (WON) has shown higher effectiveness but prior studies did not include cases with significant solid debris.
  • A trial with 48 patients compared the success of plastic versus metal stents for drainage of symptomatic WON, finding that plastic stents are non-inferior to metal stents in treatment success (87.5% vs 83.3%).
  • While the metal stent group had a shorter procedure duration, both groups had similar total procedures and minor adverse events, necessitating larger studies for definitive conclusions.
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Background: There are limited studies on the impact of gender on training and career advancement in gastroenterology.

Aim: The aim was to study this impact and understand the perceptions of work-life balance and beliefs regarding gender dynamics among gastroenterologists in India and other South Asian countries.

Methods: A web-based survey was conducted among trainees and attending physicians in South Asia from November 15, 2021, to March 30, 2022.

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Background: The relationship of inflammatory bowel disease (IBD) with osteonecrosis or avascular necrosis (AVN) is uncertain.

Methods: Systematic review to estimate the frequency of osteonecrosis in IBD was performed. Electronic databases were searched on 12 December 2022 to identify relevant studies.

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Introduction: Patients with ulcerative colitis (UC) are likely to have poor nutritional intake and increased gut losses. This study was designed to study the prevalence and predictors of nutritional deficiencies in patients with UC and their impact on the quality of life (QOL).

Methods: A prospective study was conducted among consenting patients with UC (cases) and healthy relatives of the cases (controls) visiting a university teaching hospital.

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Article Synopsis
  • Caustic ingestion can cause serious long-term health issues, including esophageal stricture and increased cancer risk, yet only a few studies have looked into the detailed tissue changes caused by such injuries.
  • A retrospective study evaluated 39 surgical specimens from patients who experienced complications due to caustic ingestion between 2008 and 2020, finding that most had significant tissue damage such as deep inflammation and structural changes.
  • The findings suggest that caustic ingestion primarily results in severe mucosal damage and inflammation, contributing to complications like refractory stricture, but no cases of dysplasia were identified in the examined tissues.
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Rising number of inflammatory bowel disease (IBD) cases in developing countries necessitate clear guidance for clinicians for the appropriate use of advanced therapies. An expert consensus document was generated to guide the usage of tofacitinib, a Janus kinase inhibitor, in ulcerative colitis. Tofacitinib is a useful agent for the induction and maintenance of remission in ulcerative colitis.

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