Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
4-Nitro and 7-nitro propranolol have been recently synthesized and characterized by us. (±)-4-NO-propranolol has been shown to act as a selective antagonist of 6-nitrodopamine (6-ND) receptors in the right atrium of rats. As part of our follow-up to this study, herein, we describe the first synthesis of (±)-3-nitroatenolol as a probe to evaluate the potential nitration of atenolol by endothelium. Chiral chromatography was used to produce pure enantiomers. By using Riguera's method, which is based on the sign distribution of ΔδH, the absolute configuration of the secondary alcohol was determined.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11013601 | PMC |
| http://dx.doi.org/10.3390/molecules29071598 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The energy landscape of folding in n-C14H30 described by a machine-learned potential.
J Chem Phys
September 2025
Yusuf Hamied Department of Chemistry. Lensfield Road, Cambridge CB2 1EW, United Kingdom.
Folding and unfolding in molecules as simple as short hydrocarbons and as complicated as large proteins continue to be an active research field. Here, we investigate folding in n-C14H30 using both density functional theory (DFT)/B3LYP calculations of 27 772 local minima and a kinetic transition network calculated for a previously reported potential energy surface (PES) obtained by fitting roughly 250 000 B3LYP energies. In addition to generating a database of minima and the transition states that connect them, these calculations and the PES based on them have been used to develop a simple and accurate model for the energy landscape.
View Article and Find Full Text PDFAlstoniaschines A‒I, nine undescribed alkaloids from Alstonia scholaris and their potential medicinal effects on diabetic nephropathy.
Phytochemistry
September 2025
State Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; Yunnan Characteristic Plant Extraction Laboratory Co. Ltd, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Educa
Alstoniaschines A‒I (1‒9), nine previously alkaloids sharing five different skeletons were obtained from the leaves of Alstonia scholaris. The structures and absolute configurations were established by their extensive spectroscopic data analyses, including NMR, HRESIMS, X-ray crystallography data, and theoretical ECD calculations. Compounds 1, 2, 3, and 9 exerted significant protective effect against oxidative stress and inflammatory damage of podocytes induced by high glucose, manifesting as the increase of superoxide dismutase, catalase, glutathione peroxidase, alongside the reductions of malondialdehyde, nitric oxide, lactate dehydrogenase.
View Article and Find Full Text PDFDesign and Synthesis of Structurally Novel Acridospiroisoxazole Derivatives and Their Antifungal Activity Study.
Chem Biodivers
September 2025
Key Lab of Natural Product Chemistry and Application at Universities of Education, Department of Xinjiang Uygur Autonomous Region, School of Chemistry and Chemical Engineering, Yili Normal University, Xinjiang, China.
The persistent threat posed by phytopathogenic fungi to agricultural systems underscores the critical need for novel fungicides. Here, we synthesized and characterized a series of novel acridospiroisoxazole derivatives (H1-H36) using H/C NMR and mass spectrometry. The absolute configuration of compound H23 was confirmed using single-crystal x-ray diffraction analysis.
View Article and Find Full Text PDFTetrasaccharide Resin Glycosides with Nitric Oxide Production Inhibitory Activity from .
J Nat Prod
September 2025
College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea.
LC-HRMS/MS-based molecular-network-guided chemical investigation of led to the isolation of seven undescribed tetrasaccharide-type resin glycosides (-). Their structures were elucidated using 1D and 2D NMR and HRESIMS analysis. Isolated resin glycosides were comprised of d-glucose, d-fucose, d-quinovose, and l-rhamnose, and these monosaccharides were partially acylated with acetyl, isobutyryl, -hexanoyl, and niloyl organic acids.
View Article and Find Full Text PDFX-ray crystal spectrometer throughput, data treatment, and configuration over the JET DTE2 and DTE3 campaigns.
Rev Sci Instrum
September 2025
Department of Physics, University of Strathclyde, Glasgow, G1 1XJ, United Kingdom.
The calibration of the JET x-ray spectrometer is presented. The absolute throughput, diffractor focusing, and instrument function of the spectrometer are presented, and the quality of the ion temperature measurement is re-assessed, particularly at the lower end. The addition of a second diffractor enables the simultaneous measurements of the spectra from H- and He-like nickel, which widens the spatial coverage of the core-ion temperature measurements for high-performance plasmas at a fixed Bragg angle range.
View Article and Find Full Text PDF