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Cloud-based Radio Access Network (Cloud-RAN) leverages virtualization to enable the coexistence of multiple virtual Base Band Units (vBBUs) with collocated workloads on a single edge computer, aiming for economic and operational efficiency. However, this coexistence can cause performance degradation in vBBUs due to resource contention. In this paper, we conduct an empirical analysis of vBBU performance on a Linux RT-Kernel, highlighting the impact of resource sharing with user-space tasks and Kernel threads. Furthermore, we evaluate CPU management strategies such as CPU affinity and CPU isolation as potential solutions to these performance challenges. Our results highlight that the implementation of CPU affinity can significantly reduce throughput variability by up to 40%, decrease vBBU's NACK ratios, and reduce vBBU scheduling latency within the Linux RT-Kernel. Collectively, these findings underscore the potential of CPU management strategies to enhance vBBU performance in Cloud-RAN environments, enabling more efficient and stable network operations. The paper concludes with a discussion on the efficient realization of Cloud-RAN, elucidating the benefits of implementing proposed CPU affinity allocations. The demonstrated enhancements, including reduced scheduling latency and improved end-to-end throughput, affirm the practicality and efficacy of the proposed strategies for optimizing Cloud-RAN deployments.
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http://dx.doi.org/10.3390/s24072365 | DOI Listing |
Talanta
August 2025
Department of Analytical Chemistry, China Pharmaceutical University, Nanjing 211198, China; Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing 210009, China; Key Laboratory of Biomedical Functional Materials, China Pharmaceu
Manganese-based nanozymes have shown great potential in sensor construction. However, building manganese-based nanozymes with high oxidase-like activity under mild preparation conditions remains challenging. Herein, for the first time it has been proposed a simple strategy using ethylenediamine to synthesize a amorphous/crystalline hetero-phase nanozyme (B-MnO-EDA) by avoiding harsh conditions.
View Article and Find Full Text PDFJ Adv Res
August 2025
College of Pharmaceutical Sciences, Jiangsu Key Laboratory of Neuropsychiatric Diseases and Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development, Soochow University, Suzhou 215123, China. Electronic address:
Introduction: The P2Y receptor (P2YR), a Gi-coupled receptor activated by UDP-glucose, plays a critical role in inflammatory responses and immune regulation. Existing P2YR antagonists face limitations such as poor bioavailability and structural homogeneity, hindering therapeutic development for inflammatory bowel disease (IBD). Drug repurposing offers a promising strategy to bypass traditional drug discovery challenges by leveraging approved drugs with established safety profiles.
View Article and Find Full Text PDFBiochem Pharmacol
July 2025
State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China. Electronic address:
Cholestatic liver injury is characterized by abnormal synthesis and excretion of bile acids, which often deteriorates into liver fibrosis, liver cancer and other diseases. Nodosin (Nod), a natural active compound derived from Chinese herb Isodon serra (Maxim.) Kudo, has been reported with valuable bioactivity for anti-cancer and anti-inflammation.
View Article and Find Full Text PDFEur J Pharmacol
October 2025
The First Affiliated Hospital of Anhui University of Science and Technology Huainan First People's Hospital, School of Medicine, Huainan, 232000, Anhui, China; The Affiliated Bozhou Hospital of Anhui University of Science and Technology (The People's Hospital of Bozhou). Bozhou, 236800, Anhui, China
Lung adenocarcinoma (LUAD), as a prevalent and life-threatening malignancy, poses a significant global health burden, particularly impacting patients and their families profoundly. Peroxiredoxin-2 (PRDX2) exhibits high expression levels in LUAD tissues. However, the identification of efficient and low-toxicity small-molecule inhibitors targeting PRDX2 from traditional Chinese medicine remains a challenging task.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
January 2026
State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), College of Pharmacy, Harbin Medical University, Heilongjiang 150081, PR China; Department of Traditional Chinese Medicine, The Second Affiliated Hospital of Zhejiang University, Zhejiang 310009, PR China; Research Unit of Health
Cervical cancer's frequent late-stage diagnosis due to asymptomatic progression necessitates advanced early detection tools. This study pioneers a SERS platform for ultrasensitive detection of miR-21-a key cervical cancer biomarker-combining thiol-modified DNA probes for high-affinity miR-21 capture with AgNP-enhanced SERS substrates that convert hybridization events into amplified Raman signals. The platform achieves sensitivity in serum and demonstrates exceptional stability through DNA-RNA duplex formation, enabling robust reproducibility in complex biofluids.
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