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http://dx.doi.org/10.1111/ans.18990 | DOI Listing |
Radiat Res
August 2025
Department of Radiation Medicine, College of Naval Medicine, Naval Medical University, Shanghai, China.
High-energy neutron radiation (HENR) induces severe cellular and tissue damage, yet effective prophylactic agents remain limited. In this study, the TLR2/NOD2 co-agonist CL429 was evaluated for its radioprotective potential against 14.1 MeV neutron exposure.
View Article and Find Full Text PDFSurg Endosc
September 2025
Department of Next Generation Endoscopic Intervention (Project ENGINE), Graduate School of Medicine, The University of Osaka, Suite 0802, BioSystems Bldg., 1-3, Yamadaoka, Suita, Osaka, 565-0871, Japan.
Objective: Rigid suction-coagulation probes constrain the wrist-like articulation that is central to robotic surgery. We therefore designed a 5-mm single-use flexible suction ball coagulator (flex-SBC) with a modified core design to restore dexterity and assessed its mechanical performance and early clinical feasibility, including the effect of the common robotic gripping strategies on suction flow.
Methods: Preclinical.
Leukemia
September 2025
I.R.C.C.S Santa Lucia Foundation, Via del Fosso di Fiorano, Rome, Italy.
At present there is no metabolic characterization of acute promyelocytic leukemia (APL). Pathognomonic of APL, PML::RARα fusion protein rewires metabolic pathways to feed anabolic tumor cell's growth. All-trans retinoic acid (ATRA) and arsenic trioxide (ATO)-based therapies render APL the most curable subtype of AML, yet approximately 1% of cases are resistant and 5% relapse.
View Article and Find Full Text PDFPhysiol Rep
September 2025
School of Kinesiology and Health Studies, Queen's University, Kingston, Ontario, Canada.
The present investigation sought to determine the cardiovascular responses to a commercially available KAATSU cuff system with rhythmic cuff inflation-deflation periods during leg exercise. Seventeen participants performed two-legged knee flexion/extension exercise at 25% of peak work rate (WR) with bilateral KAATSU cuffs applied to the proximal thigh (KAATSU) or work-rate matched control exercise (CTL). During KAATSU trials, the cuffs were set to Cycle Mode (repeated 30-s inflation; 5-s deflation) at progressively increasing cuff pressure (150-220 mmHg).
View Article and Find Full Text PDFBraz Oral Res
September 2025
Universidade Positivo, School of Health Sciences, Graduate Program in Dentistry, Curitiba, PR, Brazil.
This study assessed the effect of saliva exposure on roughness (Ra) and Vickers hardness (VHN) of two direct restorative materials, enamel, and dentin adjacent to the restorations. Enamel and dentin cavities in molars (n = 10) were restored with a) bulk-fill resin composite (Tetric N-Flow Bulk Fill, BF) with the application of a universal adhesive (Tetric N-Bond Universal) and b) alkasite restorative material (Cention N, CN) with and without the application of a universal adhesive. After 24 h (baseline), surface roughness and hardness of the restorative material and dental tissues were assessed at 100 μm from the tooth/restoration interface.
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