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Large language models are enabling rapid progress in robotic verbal communication, but nonverbal communication is not keeping pace. Physical humanoid robots struggle to express and communicate using facial movement, relying primarily on voice. The challenge is twofold: First, the actuation of an expressively versatile robotic face is mechanically challenging. A second challenge is knowing what expression to generate so that the robot appears natural, timely, and genuine. Here, we propose that both barriers can be alleviated by training a robot to anticipate future facial expressions and execute them simultaneously with a human. Whereas delayed facial mimicry looks disingenuous, facial coexpression feels more genuine because it requires correct inference of the human's emotional state for timely execution. We found that a robot can learn to predict a forthcoming smile about 839 milliseconds before the human smiles and, using a learned inverse kinematic facial self-model, coexpress the smile simultaneously with the human. We demonstrated this ability using a robot face comprising 26 degrees of freedom. We believe that the ability to coexpress simultaneous facial expressions could improve human-robot interaction.
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http://dx.doi.org/10.1126/scirobotics.adi4724 | DOI Listing |
Medicine (Baltimore)
August 2025
The First Department of Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
Patients with sepsis complicated by acute respiratory distress syndrome (ARDS) face a significantly increased risk of in-hospital death. This study aimed to identify sepsis-associated genes involved in ARDS pathogenesis and discover candidate biomarkers for its diagnosis. Gene expression profiling data from the Gene Expression Omnibus database were analyzed to identify key septic ARDS genes using differential expression analysis and weighted gene co-expression network analysis.
View Article and Find Full Text PDFFront Genet
August 2025
Obstetrical Department, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Introduction: Women with advanced maternal age (AMA) face a higher risk of pregnancy complications including preeclampsia, fetal growth restriction, and preterm birth. While placental dysfunction is implicated, the underlying mechanisms remain unclear. This study employs high-throughput sequencing-based transcriptomics to investigate AMA-associated dysregulation in placental angiogenesis, exploring links to redox imbalance.
View Article and Find Full Text PDFComput Struct Biotechnol J
July 2025
Department of Plastic Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
While the association between smoking and accelerated facial aging is well documented, the specific pathways underlying this association remain poorly understood. To investigate the shared genetic architecture between smoking and facial aging, we performed genetic analyses based on genome-wide association studies (GWAS) data. These analyses included linkage disequilibrium score regression (LDSC), pleiotropic analysis under composite null hypothesis (PLACO), functional mapping and annotation (FUMA), and multi-marker analysis of genomic annotation (MAGMA).
View Article and Find Full Text PDFClin Exp Med
August 2025
Department of Neurology, Jinhua People's Hospital, NO.267 Danxi East Road, Jindong District, Jinhua City, Zhejiang Province, China.
Patients with cirrhosis face an elevated risk of developing sepsis, leading to an escalating mortality rate. This study focuses on the link between natural killer (NK) cells, cirrhosis, and sepsis. Our goal is to identify NK cell-related genes that could serve as common diagnostic biomarkers for both conditions.
View Article and Find Full Text PDFAnal Chem
August 2025
Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium.
The human serotonin transporter (SERT) is a pertinent target for many psychiatric therapeutics and recreational drugs including new psychoactive substances. Current techniques to assess SERT inhibition typically monitor the uptake of radiolabeled or fluorescent substrates but face limitations regarding the use of nonendogenous substrates and/or low throughput. Inspired by a previously reported principle, coined 'TRACT' or 'transporter activity through receptor activation', a new bioassay to measure SERT inhibition was developed.
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