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Article Abstract
This study aimed to compare the structural features and functional properties of polysaccharides from single-clove garlic (SGPs) and multiclove garlic (MGPs) and to establish their structure-function relationships. Both SGPs and MGPs were identified as fructans consisting mainly of →1)-β-d-Fru (2→ and →6)-β-d-Fru (2→ residues but differed in average molecular weights (6.76 and 5.40 kDa, respectively). They shared similar thermodynamic properties, X-ray diffraction patterns, and high gastrointestinal digestive stability. These two purified fructans could dose-dependently scavenge free radicals, reduce oxidized metals, and effectively alleviate metronidazole-induced oxidative stress and CuSO-induced inflammation in zebrafish inhibiting the overexpression of inflammation-related proteins and cytokines. SGPs showed lower free radical scavenging activity than MGPs but higher antioxidant and anti-inflammatory activities . Taken together, the molecular weight was the main structural difference between the two garlic fructans of different varieties, which is a potential reason for their differences in biological activities.
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| http://dx.doi.org/10.1021/acs.jafc.3c07898 | DOI Listing |
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