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http://dx.doi.org/10.1016/j.jaad.2024.01.069 | DOI Listing |
Immunol Res
September 2025
Clinical Medical Research Center, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
The tumor microenvironment (TME) is a complex system composed of the extracellular matrix (ECM) and various cell types, with collagen being one of its core components. Collagen heterogeneity profoundly influences tumor progression and the remodeling of the immune microenvironment by regulating tumor cell behavior, signaling pathways, and immune evasion in TME. Different subtypes of collagen significantly affect tumor growth, metastasis, and therapeutic responses by modulating the infiltration and function of immune cells.
View Article and Find Full Text PDFJ Gastrointest Cancer
September 2025
Department of Surgery, Division of Transplant & Hepatobiliary Surgery, Organ Transplant Center, University of Iowa Health Care Medical Center, 200 Hawkins Dr, Iowa City, IA, USA.
Purpose: Gallbladder squamous cell carcinoma (SCC) is a rare subtype of gallbladder malignancy, comprising only 1-4% of cases. Ectopic expression of β-human chorionic gonadotropin (β-hCG) has been described in various epithelial cancers and is associated with aggressive behavior. We report the first known case of gallbladder SCC with diffuse β-hCG expression and markedly elevated serum β-hCG levels, aiming to explore its clinicopathological implications and potential as a prognostic biomarker.
View Article and Find Full Text PDFBiochim Biophys Acta Rev Cancer
September 2025
Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha 410008, Hunan, China; Hunan Key Laboratory of Oral Health Research & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Hunan 3D Printing Engineering Research Center of Oral Care
Innate immune cells play an important role in the immune system and are mainly responsible for the rapid response to foreign pathogens, damaged tissues, or abnormal cells. However, their immunophenotype in oral squamous cell carcinoma (OSCC) is altered due to the influence of various components within the tumour microenvironment, including tumour cells, cancer associated fibroblasts, and the extracellular matrix. This immunophenotypic shift results in the suppression of anti-tumour-related immune functions and active participation in further remodelling of the tumour microenvironment.
View Article and Find Full Text PDFCell Signal
September 2025
Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Respiratory Immunology research center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer mortality. 2.48 million new cases were reported globally in 2022, driven by rising adenocarcinoma rates linked to environmental factors such as air pollution.
View Article and Find Full Text PDFJ Vis Exp
August 2025
Department of Obstetrics and Gynecology, Affiliated Hospital of Putian University;
Long non-coding RNA MALAT1 regulates epithelial-mesenchymal transition (EMT) and metastasis in epithelial ovarian cancer (EOC) through a competing endogenous RNA (ceRNA) mechanism involving miRNA modulation. This study aimed to elucidate the molecular pathway by which MALAT1 influences EMT and metastatic behavior via interaction with miR-200c-3p and SNAI2. MALAT1 expression was genetically manipulated in the EOC cell line SK-OV-3 by either overexpression or knockdown.
View Article and Find Full Text PDF