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Article Abstract
The expression of P450 genes is regulated by -regulatory factors or -regulatory elements and influences how endogenous or xenobiotic substances are metabolized in an organism's tissues. In this study, we showed that overexpression of the cytochrome P450 gene, , led to resistance to cyantraniliprole in . The expression of increased in the midgut and remaining carcass of the CyR strain, and after repressing the expression of , the mortality of cotton aphids increased 2.08-fold after exposure to cyantraniliprole. ectopically expressing exhibited tolerance to cyantraniliprole and cross-tolerance to xanthotoxin, quercetin, 2-tridecanone, tannic acid, and nicotine. Moreover, transcription factor (XM_027994540.2) is transcribed only as the splicing variant isoform , which was found to be 504 nucleotides shorter than in . RNAi and yeast one-hybrid (Y1H) results indicated that positively regulates and binds to -acting element p (-851/-842) of to regulate its overexpression. The above results indicated that was regulated by the splicing isoform , which will help us further understand the mechanism of transcriptional adaption of cross-tolerance between synthetic insecticides and plant secondary metabolites mediated by P450s.
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| http://dx.doi.org/10.1021/acs.jafc.3c08770 | DOI Listing |
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