Article Synopsis
- Noelia Lander researches cell signaling in American trypanosomes, focusing on the role of cAMP microdomains in how these organisms sense their environment and undergo differentiation.
- She discusses how three notable research articles have shaped her understanding of regulating cAMP signals, specifically in relation to Chagas disease.
- These studies suggest that cAMP signals can be triggered by environmental factors, affecting membrane fluidity and important cellular structures involved in development.
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Article Abstract
Noelia Lander works on cell signaling in American trypanosomes and studies the role of cyclic adenosine monophosphate (cAMP) microdomains in environmental sensing and differentiation. In this mSphere of Influence, Dr. Lander reflects on three research articles in different eukaryotic models that had impacted on the way she thinks about the regulation of cAMP signals in , the etiologic agent of Chagas disease. The articles "FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility" (N. C. Surdo, M. Berrera, A. Koschinski, M. Brescia, et al., Nat Commun 8:15031, 2017, https://doi.org/10.1038/ncomms15031), "Cyclic AMP signaling and glucose metabolism mediate pH taxis by African trypanosomes" (S. Shaw, S. Knüsel, D. Abbühl, A. Naguleswaran, et al., Nat Commun 13:603, 2022, https://doi.org/10.1038/s41467-022-28293-w), and "Encystation stimuli sensing is mediated by adenylate cyclase AC2-dependent cAMP signaling in " (H. W. Shih, G. C. M. Alas, and A. R. Paredez, Nat Commun 14:7245, 2023, https://doi.org/10.1038/s41467-023-43028-1) influenced her current hypothesis that cAMP signals are generated in response to environmental cues leading to changes in membrane fluidity at the flagellar tip and the contractile vacuole complex of , structures where cAMP mediates key cellular processes for developmental progression.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10900897 | PMC |
| http://dx.doi.org/10.1128/msphere.00635-23 | DOI Listing |
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