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Purpose: Fran is one of the most popular CrossFit benchmark workouts used to control CrossFitters' improvements. Detailed physiological characterization of Fran is needed for a more specific evaluation of CrossFitters' training performance improvements. The aim of the study was to analyze the oxygen uptake (V˙O2) kinetics and characterize the energy system contributions and the degree of postexercise fatigue of the unbroken Fran.
Methods: Twenty trained CrossFitters performed Fran at maximal exertion. V˙O2 and heart-rate kinetics were assessed at baseline and during and post-Fran. Blood lactate and glucose concentrations and muscular fatigue were measured at baseline and in the recovery period.
Results: A marked increase in V˙O2 kinetics was observed at the beginning of Fran, remaining elevated until the end (V˙O2peak: 49.2 [3.7] mL·kg-1·min-1, V˙O2 amplitude: 35.8 [5.2] mL·kg-1·min-1, time delay: 4.7 [2.5] s and time constant: 23.7 [11.1] s; mean [SD]). Aerobic, anaerobic lactic, and alactic pathways accounted for 62% (4%), 26% (4%), and 12% (2%) of energy contribution. Reduction in muscle function in jumping ability (jump height: 8% [6%], peak force: 6% [4%], and maximum velocity: 4% [2%]) and plank prone test (46% [20%]) was observed in the recovery period.
Conclusions: The Fran unbroken workout is a high-intensity effort associated with an elevated metabolic response. This pattern of energy response highlights the primary contribution of aerobic energy metabolism, even during short and very intense CrossFit workouts, and that recovery can take >24 hours due to cumulative fatigue.
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http://dx.doi.org/10.1123/ijspp.2023-0201 | DOI Listing |
J Exp Biol
September 2025
Department of Biological Sciences, Binghamton University, State University of New York, Binghamton, NY 13902, USA.
Dissolved oxygen (DO) dramatically impacts the habitat use of many aquatic animals, particularly for air-breathing animals that rely on 'physical gills' for respiration while submerged. Invertebrates that use bubbles as physical gills directly uptake DO from the water for respiration. However, no vertebrate animals have yet been documented using physical gills.
View Article and Find Full Text PDFEur J Appl Physiol
September 2025
Department of Occupational Health, Psychology, and Sports Sciences, University of Gavle, Gävle, Sweden.
Aim: To summarize the literature on quantitative measures of physical demands in eldercare, with attention to differences between temporary and permanent workers, and to identify gaps to guide future physiological research.
Methods: We searched Scopus, Web of Science, and PubMed for English and Swedish peer-reviewed studies on physical demands in eldercare. Risk of bias was assessed, and descriptive data extracted.
Vet Anaesth Analg
July 2025
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
Objective: To determine the use of Air-Test in ventilated, anaesthetized dogs for evaluating oxygen uptake and to determine its potential utility in guiding the decision to perform an alveolar recruitment manoeuvre (ARM).
Study Design: Retrospective cohort study.
Animals: A total of 25 client-owned dogs undergoing general anaesthesia.
Turk J Pediatr
September 2025
Department of Cardiorespiratory Physiotherapy and Rehabilitation, Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Türkiye.
Background: Vascular changes are observed in children with cystic fibrosis (cwCF), and gender-specific differences may impact arterial stiffness. We aimed to compare arterial stiffness and clinical parameters based on gender in cwCF and to determine the factors affecting arterial stiffness in cwCF.
Methods: Fifty-eight cwCF were included.
Small
September 2025
Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by cognitive decline and the accumulation of amyloid-β (Aβ) plaques, with current treatments offering only limited efficacy. Targeted photo-oxygenation of Aβ using small-molecule photosensitizers has emerged as a promising strategy to modulate amyloid aggregation and mitigate associated toxicity. In this work, the rational design and synthesis of donor-engineered, benzimidazole-functionalized aggregation-induced emission (AIE) photosensitizer with optimized photophysical and morphological properties for multimodal theranostic applications in AD is analyzed and reported.
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