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The auto-encoder (AE) based image fusion models have achieved encouraging performance on infrared and visible image fusion. However, the meaningful information loss in the encoding stage and simple unlearnable fusion strategy are two significant challenges for such models. To address these issues, this paper proposes an infrared and visible image fusion model based on interactive residual attention fusion strategy and contrastive learning in the frequency domain. Firstly, the source image is transformed into three sub-bands of the high-frequency, low-frequency, and mid-frequency for powerful multiscale representation from the prospective of the frequency spectrum analysis. To further cope with the limitations of the straightforward fusion strategy, a learnable coordinate attention module in the fusion layer is incorporated to adaptively fuse representative information based on the characteristics of the corresponding feature maps. Moreover, the contrastive learning is leveraged to train the multiscale decomposition network for enhancing the complementarity of information at different frequency spectra. Finally, the detail-preserving loss, feature enhancing loss and contrastive loss are incorporated to jointly train the entire fusion model for good detail maintainability. Qualitative and quantitative comparisons demonstrate the feasibility and validity of our model, which can consistently generate fusion images containing both highlight targets and legible details, outperforming the state-of-the-art fusion methods.
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http://dx.doi.org/10.1038/s41598-023-51045-9 | DOI Listing |
Nat Biotechnol
September 2025
Key Laboratory of RNA Innovation, Science and Engineering, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.
Targeted protein degraders hold potential as therapeutic agents to target conventionally 'undruggable' proteins. Here, we develop a high-throughput screen, DEath FUSion Escaper (DEFUSE), to identify small-molecule protein degraders. By conjugating the protein of interest to a fast-acting triggerable death protein, this approach translates target protein degradation into a cell survival phenotype to illustrate the presence of degraders.
View Article and Find Full Text PDFPathol Res Pract
September 2025
Department of Pathology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi'an, China. Electronic address:
Background: Dermal clear cell sarcoma (DCCS) is a rare malignant mesenchymal neoplasm. Owing to the overlaps in its morphological and immunophenotypic profiles with a broad spectrum of tumors exhibiting melanocytic differentiation, it is frequently misdiagnosed as other tumor entities in clinical practice. By systematically analyzing the clinicopathological characteristics, immunophenotypic features, and molecular biological properties of DCCS, this study intends to further enhance pathologists' understanding of this disease and provide a valuable reference for its accurate diagnosis.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Smart Manufacturing, Industrial Perception and Intelligent Manufacturing Equipment Engineering Research Center of Jiangsu Province, Nanjing Vocational University of Industry Technology, Nanjing, Jiangsu, China.
In the field of quality control, metal surface defect detection is an important yet challenging task. Although YOLO models perform well in most object detection scenarios, metal surface images under operational conditions often exhibit coexisting high-frequency noise components and spectral aliasing background textures, and defect targets typically exhibit characteristics such as small scale, weak contrast, and multi-class coexistence, posing challenges for automatic defect detection systems. To address this, we introduce concepts including wavelet decomposition, cross-attention, and U-shaped dilated convolution into the YOLO framework, proposing the YOLOv11-WBD model to enhance feature representation capability and semantic mining effectiveness.
View Article and Find Full Text PDFACS Nano
September 2025
State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
Optical imaging offers high sensitivity and specificity for noninvasive cancer detection, but conventional techniques suffer from limited probe accumulation, tissue autofluorescence, and poor depth resolution. Afterglow luminescence overcomes autofluorescence by emitting persistent light after excitation, yet its utility in vivo remains hindered by weak tumor enrichment and two-dimensional readouts lacking spatial context. Here, we report luminescent-magnetic nanoparticles (LM-NPs) coencapsulating luminescent trianthracene (TA) molecules and iron oxide cores within the amphiphilic polymer pluronic-F127.
View Article and Find Full Text PDFHum Brain Mapp
September 2025
Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, and Emory University, Atlanta, Georgia, USA.
Investigating neuroimaging data to identify brain-based markers of mental illnesses has gained significant attention. Nevertheless, these endeavors encounter challenges arising from a reliance on symptoms and self-report assessments in making an initial diagnosis. The absence of biological data to delineate nosological categories hinders the provision of additional neurobiological insights into these disorders.
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