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Background: Mortality is critical information in evaluating the benefits of cancer screening. However, 5-y survival rates and incidence, without mortality, have been frequently communicated to the public. Based on the literature that people's perceptions and judgments can be altered by the way of presenting health statistics, the current study examined whether mortality alongside 5-y survival and incidence would influence laypeople's perceptions of the effectiveness of cancer screening and screening intention.
Methods: In an online-based experimental survey conducted in South Korea in October 2022, 300 adults were randomly assigned to 1 of 2 groups (mortality: no v. yes) to be presented with 3 different cancers (A, B, and C). The perceived effectiveness of cancer screening and screening intention were measured using 7-point scales for each cancer.
Results: Across all cancers, participants in the no-mortality group perceived cancer screening to be more effective and were more willing to undergo screening compared with those in the mortality group, although the results were not statistically significant on the intention.
Conclusions: In general, mortality had an effect of decreasing the perceived effectiveness of cancer screening and screening intention compared with no mortality, although the effect on the intention was not statistically significant.
Implications: When communicating the benefits of cancer screening to the public, mortality statistics may play a role in mitigating the potentially inflated perception of the benefits of cancer screening and screening intention.
Highlights: Five-year survival rates, either alone or with incidence rates, are frequently communicated to the public in the context of the benefits of cancer screening.However, 5-y survival rates can sometimes be inflated without a reduction in mortality.Including mortality statistics in communications decreased the perceived effectiveness of cancer screening and screening intentions.Mortality information needs to be communicated in the benefits of cancer screening.
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http://dx.doi.org/10.1177/0272989X231218278 | DOI Listing |
Biosens Bioelectron
September 2025
College of Chemistry, Jilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, Jilin University, Qianjin Street 2699, Changchun, 130012, China. Electronic address:
Papillary thyroid carcinoma (PTC) is the most prevalent form of thyroid cancer with a high incidence among endocrine malignancies. It tends to metastasize early in lymph nodes and differs markedly from other subtypes in biological behavior, clinical management, and prognosis. Therefore, accurately distinguishing PTC from other pathological subtypes is crucial for guiding diagnosis and treatment decisions.
View Article and Find Full Text PDFCancer Nurs
September 2025
Author Affiliation: School of Nursing, University of Connecticut, Storrs.
Background: Breast cancer is a leading cause of cancer-related morbidity and mortality and imposes substantial financial strain on individuals and society. Minoritized groups, particularly Black/African American (AA) women, face a heightened risk of financial toxicity during treatment, even after accounting for socioeconomic differences.
Objective: The aim of this study was to explore and provide meaningful interpretations of the financial experiences of Black/AA breast cancer survivors (BCSs).
JMIR Med Inform
September 2025
Department of Hepatobiliary and Vascular Surgery, First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
Background: Primary liver cancer, particularly hepatocellular carcinoma (HCC), poses significant clinical challenges due to late-stage diagnosis, tumor heterogeneity, and rapidly evolving therapeutic strategies. While systematic reviews and meta-analyses are essential for updating clinical guidelines, their labor-intensive nature limits timely evidence synthesis.
Objective: This study proposes an automated literature screening workflow powered by large language models (LLMs) to accelerate evidence synthesis for HCC treatment guidelines.
Chem Biodivers
September 2025
School of Traditional Chinese Materia Medica, Key Laboratory of Ethnomedicine Material Basis & Pharmacological Mechanisms, Shenyang, Shenyang Pharmaceutical University, Shenyang, China.
In intracellular signaling, mammalian target of rapamycin (mTOR) as an important mammalian target for breast cancer therapy, plays a key role in receiving upstream signals from growth factor receptors such as epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2). Using 30 compounds from Meehania fargesii var. Radicans, structure-based virtual screening and molecular docking were performed to develop novel and safe breast cancer targeting inhibitors from natural products.
View Article and Find Full Text PDFElectroporation is a promising technology utilizing electrical pulses for macromolecule delivery and soft-tissue ablation, with applications that include next-generation prophylactics and the treatment of genetic diseases such as cancer. This study demonstrates a high-throughput capable 3D tissue culture model for quantification of the reversible and irreversible electroporation thresholds for a given electroporation protocol. By using a non-uniform electric field and analyzing the spatial distribution of transfected cells, both reversible and irreversible thresholds can be identified within a single sample, increasing the efficiency at which electroporation protocols can be characterized, especially for in vivo translation.
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