Plant-Derived Anticancer Candidates Targeting mTOR, EGFR, HER2: Insights From Molecular Docking and Dynamics Simulations.

In intracellular signaling, mammalian target of rapamycin (mTOR) as an important mammalian target for breast cancer therapy, plays a key role in receiving upstream signals from growth factor receptors such as epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2). Using 30 compounds from Meehania fargesii var. Radicans, structure-based virtual screening and molecular docking were performed to develop novel and safe breast cancer targeting inhibitors from natural products.

Design and Parameter Identification for a Positioning Platform with a Large Stroke and High Precision for Segmented Mirrors.

An active optical system with three segmented mirrors was proposed to verify the co-focus and co-phase progress. In this system, a kind of large-stroke and high-precision parallel positioning platform was specially developed to help support the mirrors and reduce the error between them, which can move in three degrees of freedom out of plane. The positioning platform was composed of three flexible legs and three capacitive displacement sensors.

Measurement of internal stray radiation of a thermal infrared spectrometer based on temperature variation.

The level of internal stray radiation is an important criterion to evaluate the performance of a thermal infrared spectrometer. In this study, a novel method is proposed and evaluated to measure the internal stray radiation of a thermal infrared spectrometer based on temperature variation. The proposed method was used to measure the internal stray radiation values of an existing instrument.