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http://dx.doi.org/10.1038/s41435-023-00242-7 | DOI Listing |
Cancer Med
September 2025
Division of Clinical & Translational Cancer Research, Medical Sciences Campus, University of Puerto Rico Comprehensive Cancer Center, San Juan, Puerto Rico.
Background: Gastric cancer (GC) is the fourth leading cause of cancer-related death globally. Tumor profiling has revealed actionable gene alterations that guide treatment strategies and enhance survival. Among Hispanics living in Puerto Rico (PRH), GC ranks among the top 10 causes of cancer-related death.
View Article and Find Full Text PDFBioorg Chem
September 2025
The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China; School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China; Qinghai Provincial Key Laboratory of Tibetan Medicine Research, North
The high prevalence and drug resistance of superficial fungal infections (SFIs) pose a serious global public health challenge, urgently necessitating the development of novel antifungal drugs with unique structures and novel targets. Evodiamine derivatives are promising antifungal drug leads, yet they suffer from suboptimal activity and unclear action mechanisms. In this study, a series of N(14)-phenyl evodiamine derivatives were designed, synthesized and tested for their biological activities.
View Article and Find Full Text PDFJ Exp Med
November 2025
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Host-pathogen interactions involve two critical strategies: resistance, whereby hosts clear invading microbes, and tolerance, whereby hosts carry high pathogen burden asymptomatically. Here, we investigate mechanisms by which Salmonella-superspreader (SSP) hosts maintain an asymptomatic state during chronic infection. We found that regulatory T cells (Tregs) are essential for this disease-tolerant state, limiting intestinal immunopathology and enabling SSP hosts to thrive, while facilitating Salmonella transmission.
View Article and Find Full Text PDFJ Agric Food Chem
September 2025
College of Basic Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi 030000, China.
Atherosclerosis (AS) is increasingly recognized as a disease influenced not only by lipid metabolism and inflammation but also by the gut microbiota and their bioactive metabolites. Isoquercitrin (ISO), a natural flavonoid with food-medicine homology, has shown promising antiatherosclerotic potential, yet its underlying mechanisms remain unclear. In this study, ISO administration significantly reduced plaque burden, improved lipid profiles, and restored gut microbial balance by enriching beneficial taxa, such as , , and .
View Article and Find Full Text PDFInflamm Bowel Dis
September 2025
Gut Microbes and Health Programme, Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.
Background: Intestinal cells receive incoming signals from neighboring cells and microbial communities. Upstream signaling pathways transduce these signals to reach transcription factors (TFs) that regulate gene expression. In inflammatory bowel disease (IBD), most single nucleotide polymorphisms (SNPs) are in non-coding genomic regions containing TF binding sites.
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