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Article Abstract
The prevalence of multidrug-resistant is of global concern, and vaccines are urgently needed. The iron-regulated surface determinant protein B (IsdB) of was investigated as a vaccine candidate because of its essential role in bacterial iron acquisition but failed in clinical trials despite strong immunogenicity. Here, we reveal an unexpected second function for IsdB in pathogen-host interaction: the bacterial fitness factor IsdB triggers a strong inflammatory response in innate immune cells via Toll-like receptor 4 and the inflammasome, thus acting as a novel pathogen-associated molecular pattern of . Our discovery contributes to a better understanding of how modulates the immune response, which is necessary for vaccine development against the sophisticated pathogen.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10790753 | PMC |
| http://dx.doi.org/10.1128/mbio.00225-23 | DOI Listing |
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