The central dorsal component of the dorsoradial ligament of the trapeziometacarpal joint: Cadaveric and sonographic validation.

Purpose: Osteoarthritis of the trapeziometacarpal joint is very common, especially in females, and is closely associated with ligamentous laxity and joint subluxation. The dorsoradial ligament (DRL) remains largely unexplored in ultrasound studies despite its clinical relevance. This study aimed to identify the central fascicle of the DRL anatomically and ultrasonographically and to establish a standardized ultrasound examination protocol.

Defective Lymphangiogenesis and Iron Removal after Hemarthrosis in FVIII-deficient Mice are Rectified with Therapeutic FVIII Administration - Implications for Joint Health.

Background: Maladaptive lymphangiogenesis after hemarthrosis in Factor(F)VIII deficient (KO) mice facilitates synovial iron accumulation.

Objectives: To investigate the impact of FVIII treatment on lymphangiogenesis, iron clearance, and joint health after hemarthrosis.

Methods: Two days after knee injury/bleed (sub-patellar needle puncture) FVIII-KO mice were separated into three groups receiving (1) intravenous saline, (2) recombinant human (rh)FVIII for 2 days, or (3) murine (m)FcFVIII for 14 days.

Preparation and characterization of different immobilized and chemically modified preparations of lipase B from Candida antarctica: is it the activation energy a good indicator of the biocatalyst expressed activity?

Lipase B from Candida antarctica immobilized on octyl (via interfacial activation) and octyl-vinyl sulfone (covalently attached) agarose beads via different immobilization protocols was submitted to amination and/or glutaraldehyde modifications. The catalytic performance of the resulting biocatalysts significantly varied across different substrates: using octyl-CALB with the double modification, activity increased 3.5 fold versus triacetin and decreased by 5 % using R-methyl mandelate, while using the covalent biocatalyst, activity increase by 2.

Facial paralysis and vestibular Schwannoma surgery: new classification system for assessing non-total tumor resection.

Objective: To compare the outcomes of vestibular schwannoma surgeries over the past decade, focusing on surgical approach, facial nerve function, tumor recurrence, and to standardize a classification system for the extent of tumor resection.

Study Design: A retrospective cohort study involving 197 patients who underwent vestibular schwannoma surgery between January 2014 and December 2023.

Methods: Data on demographics, tumor characteristics, surgical approach, and facial nerve function were collected.

Impact of toll-like receptors on food allergy. mechanisms involved and scientific evidence.

Food allergy (FA) is an exacerbated immune system response to harmless food antigens following sensitization. The incidence of FA has risen significantly over the past two decades, a trend often attributed to modern lifestyle factors such as dietary patterns, antibiotic use, and urban environments. Sensitization may result from a compromised intestinal barrier caused by inflammatory bowel diseases, genetic predisposition, or a combination of both.

Comparative and developmental anatomy of the fibularis brevis muscle: morphological variants and their clinical significance.

Background: The fibularis brevis muscle (FBM)is a key stabilizer of the lateral ankle, yet its anatomy exhibits a notable degree of variability. While often overshadowed by the fibularis longus, FBM and its tendon (FBT) play critical roles in foot eversion, proprioception, and surgical reconstruction. However, inconsistent terminology and limited integrative studies have hindered comprehensive clinical understanding.

Effects of plantar static pressure distribution in subject with bilateral hallux limitus: a detailed case-control study.

Background: Hallux limitus (HL) is defined as the restriction of dorsiflexion (DF) in the first metatarsophalangeal joint (IMTFJ) under closed kinetic chain conditions, where the distal segment is fixed and the foot is in contact with the ground. This biomechanical condition compromises the Windlass mechanism during the propulsive phase of gait, generating pain and functional disability. Therefore, the aim of this research was to examine the aspect of foot shape linked to distribution of static plantar pressure in individuals with bilateral HL compared to subjects with normal foot.

Sex Differences in State-of-the-Art Management for Left Main Disease.

Background: Although higher mortality has been reported among women undergoing coronary revascularization for left main coronary artery disease (LMD), it remains unclear whether contemporary approaches can address these disparities.

Objectives: We investigated sex differences in outcomes using the DEFINE-LM (deferral of coronary revascularization based on instantaneous wave-free ratio evaluation for left main coronary artery disease) registry, in which state-of-the-art management was employed.

Methods: We analyzed 314 patients from an international, multicenter registry, where all patients received state-of-the-art management, including physiology-guided revascularization decisions, intracoronary imaging-optimized drug-eluting stent deployment, or surgical procedures with internal thoracic artery grafts, alongside guideline-directed medical therapy.

Physiology-Guided Complete Revascularization in Older Patients With Myocardial Infarction: Three-Year Outcomes of a Randomized Clinical Trial.

Importance: Complete revascularization in older patients with myocardial infarction (MI) and multivessel disease has been shown to reduce cardiovascular death and MI at 1 year. However, the durability of this benefit over longer follow-up periods has been questioned by recent studies.

Objective: To determine whether the benefit of physiology-guided complete treatment, compared with culprit-only treatment, is sustained at 3 years in older patients with MI and multivessel disease.

Systematic review and modelling of seroprevalence in humans, Europe, 2000 to 2021.

BACKGROUND is a zoonotic protozoan capable of infecting warm-blooded animal species and humans. Although toxoplasmosis presents mostly as mild or asymptomatic infection in immunocompetent individuals, in unborn children and people with weakened immune systems, the disease can be severe with ocular, neurological or multi-systemic manifestations and even death.AIMWe aimed to collate and analyse data on seroprevalence in humans to model and compare age-dependent prevalence in geographic regions in Europe.

Mandibular Rotated Pediculated Flap: A Technique to Increase Peri-Implant Mucosa Thickness.

Objectives: Peri-implant soft tissue is considered critical for maintaining peri-implant health, minimizing esthetic and biological complications, and promoting the long-term stability of implant-supported restorations. This article describes a straightforward and minimally invasive technique for augmenting the peri-implant mucosa thickness (MT) in the mandibular posterior area using a rotated pedicled flap (MRPF).

Clinical Considerations: The described surgical procedure was conducted on sixteen systemically healthy adults (8 males, 8 females) with posterior mandibular partial edentulism and a thin tissue phenotype.

Effect of Abutment Color and Soft Tissues Changes on the Esthetic Outcome of Implant-Supported Lithium Disilicate Restorations.

Objetive: To evaluate the influence of titanium and gold-shaded titanium as well as peri-implant soft tissue thickness on the optical outcome of implant-supported lithium disilicate single crowns.

Methods: Eighteen patients received an anterosuperior implant (Astra Tech Implant System EV). Two customized titanium abutments (gold and conventional) were fabricated, and a lithium disilicate crown was placed.

Rationale and design of European microCirculatory Resistance and Absolute Flow Team: The Euro-CRAFT Registry.

Introduction: Coronary microvascular dysfunction (CMD) is increasingly recognized as an important cause of anginal symptoms and poor outcomes. Angina with non-obstructive coronary arteries (ANOCA) is often related to CMD. While physiological assessment of microcirculatory function by coronary bolus thermodilution is widely practiced, more precise and reproducible methodology as well as systematic assessment are necessary.

Tracking the Spatial and Functional Dispersion of Vaccine-Related Canine Distemper Virus Genotypes: Insights from a Global Scoping Review.

Canine morbillivirus (CDV), the cause of canine distemper, is a pathogen affecting many hosts. While modified live virus (MLV) vaccines are crucial for controlling the disease in dogs, cases of vaccine-related infections have been found in both domestic and wild animals. Specifically, the America-1 and Rockborn-like vaccine genotypes are concerning due to their spread and ability to transmit between different species.

Enhanced Accuracy in Jump Power Estimation Using Photoelectric Cell System and GRS80 Location-Specific Gravitational Acceleration.

Power is essential in sports and is typically calculated using a standard gravity value of = 9.81 m·s. However, this value varies according to altitude and geographical latitude.

Cilastatin Attenuates Acute Kidney Injury and Reduces Mortality in a Rat Model of Sepsis.

Sepsis is a life-threatening condition caused by an abnormal host response to infection, leading to organ dysfunction and potentially death. Acute kidney injury (AKI) is a critical complication of sepsis. Various pathways, especially signaling through Toll-like receptors (TLRs) and the nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome, contribute to inflammation and tissue damage.

Relationship of Melatonin Levels in Blood and Urine with Sleep Quality in Children Admitted to Pediatric Intensive Care Unit.

Objectives: Melatonin regulates the sleep-wake cycle, which may be altered in children admitted to the pediatric intensive care unit (PICU). The aim is to analyze whether blood and urine melatonin levels are related to sleep quality in children admitted to the PICU.

Methods: A single-center, prospective observational study was conducted at the PICU in a tertiary referral center in Madrid, Spain.

Factors Associated with Persistent Metatarsal Pain in Patients with Rheumatoid Arthritis in Remission: Clinical Implications and Multivariable Analysis in a Cross-Sectional Study.

: Foot pain often persists in patients with rheumatoid arthritis (RA), even during clinical remission. However, its causes are not fully understood. Identifying factors specifically associated with metatarsal pain, rather than generalized foot pain, may improve targeted management strategies.

In Vivo Safety and Efficacy of Thiosemicarbazones in Experimental Mice Infected with Oocysts.

: is a globally widespread parasite responsible for toxoplasmosis, a zoonotic disease with significant impact on both human and animal health. The current lack of safe and effective treatments underscores the need for new drugs. Earlier, thiosemicarbazones (TSCs) and their metal complexes have shown promising activities against .

Self-Perception and Assessment of Antibiotic Therapy Knowledge in Dental Students in Spain: A Cross-Sectional Observational Study.

: The development of antimicrobial resistance is a major public health issue, in which dentists play a significant role by prescribing 7-11% of worldwide antibiotics. The aim of this study is to evaluate the self-perception and knowledge of antibiotic therapy in fifth-year undergraduate dental students. : This is a cross-sectional observational study based on the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) guidelines.

Emotional Status in Relation to Metacognitive Self-Awareness and Level of Functional Disability Following Acquired Brain Injury.

: Impairment in self-awareness (ISA) is one of the common consequences of an acquired brain injury (ABI) and is associated with anosodiaphoria. Collectively, these co-occurring neuropsychological disorders pose significant obstacles in the neurorehabilitation of moderate-to-severe ABI patients. Individuals who recover from ISA may present with anxiety and/or depression as adaptive reactions to the ABI, along with related functional disabilities.

Long-term effects of face-to-face supervision versus telephone supervision during a community-based pulmonary rehabilitation programme in people with COPD using minimal equipment: a randomized controlled trial.

Background: Pulmonary rehabilitation is a key and effective treatment for people with chronic obstructive pulmonary disease (COPD) although lack of accessibility is a barrier. The aim of this study was to compare the effects of face-to-face supervision (FFS) with those of telephone supervision (TS) during a community-based pulmonary rehabilitation programme to increase functional exercise capacity in people with COPD using minimal equipment. In addition, physical activity level, health-related quality of life, psychological status, exercise self-efficacy, number of exacerbations and adherence were analysed.

Intrauterine-diagnosed fetal intracranial adamantinomatous craniopharyngioma: A case report with histopathological and molecular characterization.

Craniopharyngiomas are the most common non-neuroepithelial intracerebral neoplasms in children but rarely occur before birth, and are typically associated with a poor prognosis. We present the case of a 39-year-old woman with a spontaneously conceived singleton pregnancy. At 20 weeks of gestation, ultrasound detected a 44×25 mm heterogeneously hyperechogenic intracranial mass located at the base of the sphenoid bone, extending bilaterally.

Healthcare-related transmission of mobile genetic elements co-carrying and 16S rRNA methyltransferase genes in multiple .

Aminoglycosides are used in the treatment of serious infections with Gram-negative bacteria, especially those resistant to beta-lactams and carbapenems. 16S rRNA methyltransferases (16S-RMTase) are capable of conferring resistance to nearly all aminoglycosides. They are sometimes detected in combination with .

Clinical Trends in the Prevention of Peri-Implantitis: Spanish Society of Periodontology (SEPA) Foundation Survey Using the Delphi Method.

Objective: To assess clinical trends to prevent peri-implantitis in applying a two-step survey based on the Delphi method.

Material And Methods: A panel of participants aged < 45 years old selected by the Spanish Society of Periodontology (SEPA) was asked to answer a survey with 75 statements prepared by a steering committee. Items were divided into 5 major areas: etiopathogenesis and epidemiology, surgical, implant, and prosthetic-related factors on the onset/progression of peri-implantitis, and self- and professional-administered oral hygiene.