Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Hepcidin, an antimicrobial peptide (AMP), is a well-conserved molecule present in various species such as fish, amphibians, birds, reptiles, and mammals. It exhibits broad-spectrum antimicrobial activity and holds a significant role in the innate immune system of host organisms. The northern snakehead (Channa argus) has become a valuable freshwater fish in China and Asia. In this investigation, the cDNA encoding the hepcidin gene of northern snakehead was cloned and named caHep. The amino acid sequences and protein structure of caHep are similar to those of hepcidins from other fish. The eukaryotic expression product of the caHep gene showed broad-spectrum antibacterial activity. Scanning electron microscope analysis indicated that the caHep peptide inhibited bacterial growth by damaging their cell membranes. Lipopolysaccharide (LPS) injection induced significant expression of caHep, implying the involvement of caHep in the innate immune response of northern snakeheads. This investigation showed that the caHep peptide is potentially a robust antibacterial drug against bacterial diseases in aquaculture animals.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12602-023-10195-y | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Unravelling the genetic landscape of Channa argus in Shandong Province: Insights into population differentiation, adaptation and conservation from whole-genome resequencing.
J Fish Biol
August 2025
Department of Genetics and Breeding, Shandong Freshwater Fisheries Research Institute, Jinan, China.
The snakehead (Channa argus) is an economically important freshwater fish species. Understanding how geographical isolation affects population differentiation is important for understanding the processes that shape biodiversity. We examined four wild populations [Dongping Lake (DP), Nansi Lake (NS), Yihe River (YH) and Yellow River Estuary (HH)] and an aquaculture population [Weishan Lake (WL)] in Shandong Province using whole-genome resequencing for the first time.
View Article and Find Full Text PDFIdentification and functional characterization of cGAS and cGAS-like in snakehead Channa argus.
Fish Shellfish Immunol
October 2025
School of Marine Science and Engineering, Qingdao Agricultural University, Qingdao, Shandong Province, 266109, China; Laboratory for Marine Biology and Biotechnology, Qingdao Marine Science and Technology Center, Qingdao, Shandong Province, 266237, China. Electronic address:
In mammals, cyclic GMP-AMP synthase (cGAS) senses cytosolic dsDNA to trigger type I interferon (IFN) response via the sting signalling, but its regulatory role in fish remains unclear. In the present study, cGAS and cGAS-like (cGASL) were identified in the snakehead (Channa argus), but they differ in the organization of two domains, NTase domain, MAB21 domain, with an additional transmembrane domain in cGASL. It is further revealed that cGAS can bind with Sting to enhance the production of type I IFN and IFN-stimulated genes (ISGs), such as viperin, mx, and its entire molecule with all domains is necessary for its functioning.
View Article and Find Full Text PDFChanna argus optimizer for solving numerical optimization and engineering problems.
Sci Rep
July 2025
Hubei Communications Technical College, Wuhan, 430079, China.
In this study, we introduce the Channa Argus Optimizer (CAO), a novel swarm-based meta-heuristic algorithm that draws inspiration from the distinctive hunting and escaping behavior observed in Channa Arguses in the natural world. The CAO algorithm mainly emulates the hunting and escaping behavior of Chinna Argus to realize a tradeoff between exploitation and exploration in the solution space and discourage premature convergence. The competitiveness and effectiveness of CAO are validated utilizing 29 typical CEC2017 and 10 CEC2020 unconstrained benchmarks and 5 real-world constrained optimization mechanical engineering issues.
View Article and Find Full Text PDFOptimal Isatidis Radix extract enhances growth, immunity, modifies immune-gene action and intestinal health in hybrid snakehead (Channa maculata ♀ × Channa argus ♂) against rhabdovirus.
Fish Shellfish Immunol
October 2025
Key Laboratory of Tropical and Subtropical Fishery Resources Application and Cultivation, Ministry of Agriculture and Rural Affairs, Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, Guangdong, 510380, PR China. Electronic address:
Isatidis Radix is a traditional Chinese medicinal herb renowned for its broad-spectrum antimicrobial, antiviral, and anti-inflammatory properties. This study assessed the effects of Isatidis Radix extract on growth performance, non-specific immunity and intestinal health and disease resistance in hybrid snakehead (Channa maculata ♀ × Channa argus ♂). Fish were fed diets supplemented with Isatidis Radix extract at concentrations of 0 (C), 0.
View Article and Find Full Text PDFToxic effects of microplastics on freshwater fish (Channa argus): mechanisms of inflammation, apoptosis, and autophagy.
Aquat Toxicol
September 2025
Joint Laboratory of Modern Agricultural Technology International Cooperation, Ministry of Education, Key Laboratory of Animal Production, Product Quality and Security, Jilin Provincial Key Laboratory of Animal Nutrition and Feed Science, College of Animal Science and Technology, Jilin Agricultural U
This study examined the impact of Polystyrene microplastics (PS-MPs) on inflammation, apoptosis and autophagy within the liver, intestine, kidney, and gill of northern snakehead (Channa argus). In this study, 600 snakeheads (mean body weight: 10.5 ± 0.
View Article and Find Full Text PDF