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Nationwide outbreaks of lumpy skin disease (LSD) were observed in Thailand in 2021. A better understanding of its disease transmission is crucial. This study utilized a kernel-based approach to characterize the transmission of LSD between cattle herds. Outbreak data from the Khon Kaen and Lamphun provinces in Thailand were used to estimate transmission kernels for each province. The results showed that the majority of herd-to-herd transmission occurs over short distances. For Khon Kaen, the median transmission distance from the donor herd was estimated to be between 0.3 and 0.8 km, while for Lamphun, it ranged from 0.2 to 0.6 km. The results imply the critical role that insects may play as vectors in the transmission of LSD within the two study areas. This is the first study to estimate transmission kernels from data on LSD outbreaks in Thailand. The findings from this study offer valuable insights into the spatial transmission of this disease, which will be useful in developing prevention and control strategies.
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http://dx.doi.org/10.3390/v15112196 | DOI Listing |
J Vet Diagn Invest
September 2025
Biology Department; Faculty of Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Lumpy skin disease (LSD) is a viral disease that affects livestock and is caused by the lumpy skin disease virus (LSDV). An outbreak of LSD in any country can lead to acute economic damage for livestock owners. The significance of prompt and accurate diagnosis in managing this viral disease cannot be overstated.
View Article and Find Full Text PDFAntiviral Res
September 2025
State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730030, P.R. China; Yazhouwan National Laboratory, Sanya 572024, P. R. China. Electronic addres
Due to the lack of timely vaccine prevention and effective drug treatment, lumpy skin disease is increasingly becoming a global epidemic, including in China. There is an urgent need to explore the pathogenic mechanism of lumpy skin disease virus (LSDV) and develop practical therapeutic approaches. The present study provides concrete evidence for the simultaneous induction and activation of nuclear ATM-mediated double-strand break and ATR kinase-dependent single-strand break signaling cascades during LSDV replication in the cytoplasm.
View Article and Find Full Text PDFVet Ital
September 2025
Istituto Zooprofilattico Sperimentale della Sardegna.
Lumpy Skin Disease virus (LSDV) is a Capripoxvirus that causes Lumpy Skin Disease (LSD), a highly contagious disease of cattle transmitted primarily by blood-feeding arthropods, but also through direct contact and fomites. On 20 June 2025, an outbreak was reported in a beef cattle farm in Orani (Nuoro, Sardinia, Italy), where 21 of 131 animals showed typical clinical signs. Fourteen samples tested positive for LSDV by real-time PCR, and selected specimens underwent whole genome sequencing, generating three high-quality consensus sequences.
View Article and Find Full Text PDFThe lumpy skin disease (LSD), caused by the lumpy skin disease virus (LSDV), represents an emerging infectious disease that poses substantial economic losses to the cattle industries in China. This study aimed to investigate the epidemiological characteristics of LSDV in Yunnan Province, Southwest China, from 2019 to 2023. A Taqman-probe-based real-time PCR (qPCR) assay was developed for the molecular detection of LSDV nucleotides.
View Article and Find Full Text PDFViruses
August 2025
Biomedical Sciences & Molecular Biology, College of Medicine and Dentistry, James Cook University, Townsville, QLD 4811, Australia.
Lumpy skin disease virus (LSDV), a transboundary pathogen threatening cattle health in South and Southeast Asia, presents growing challenges for disease control. This study combined serological, molecular, and genomic approaches to investigate LSDV in Barura Upazila, Bangladesh. Serological screening of 424 cattle using a commercial ELISA revealed a high seroprevalence of 55.
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