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To compare surgical magnet repositioning (SMR) and noninvasive manual magnet repositioning (MMR) as treatments for partial magnet dislocation (PMD) of the internal magnet in a cochlear implant (CI) caused by magnetic resonance imaging (MRI). The primary objective was the success rate, while the secondary objectives were total postinterventional CI downtime and complications. This single-center retrospective study was conducted at a tertiary referral medical center. Patients with CI treated for PMD between January 1, 2007 and September 30, 2022 were included. SMR served as primary treatment until June 2019 and as secondary treatment after the introduction of MMR. A total of 51 cases of PMD were observed in 42 patients and 43 devices (18 ♀; 24 ♂; 12 with bilateral CI). MMR was performed successfully in 19 out of 20 cases (95%), while 32 cases were managed successfully by SMR. The median age at first magnet repositioning was 53.8 years (minimum 19 years, maximum 93 years). When MMR was performed, the mean time from diagnosis to treatment (0.5 ± 1.5 days vs 9.8 ± 7.6 days; < .01), the mean time from repositioning to CI reactivation (1.4 ± 4.3 days vs 13.1 ± 6.7 days; < .01), and the mean total CI downtime (1.9 ± 4.8 days vs 22.9 ± 11.9 days; < .01) were significantly shorter compared to SMR. Significantly fewer complications were experienced with MMR [ = 0 (0%) vs = 8 (25%); = .04]. In case of PMD caused by MRI, noninvasive MMR shows a high success rate with a shorter total CI downtime as well as a lower complication rate compared to SMR. Therefore, MMR should be considered as first line treatment with SMR as a second option in case of failure.
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http://dx.doi.org/10.1177/01455613231206297 | DOI Listing |
Structure
August 2025
Centre for Biomolecular Magnetic Resonance, Institute for Biophysical Chemistry, Goethe University of Frankfurt/Main, Frankfurt/Main, Germany. Electronic address:
The third intracellular loop (ICL3) of the β1-adrenergic receptor (β1AR) plays a critical role in regulating G protein coupling, yet the structural basis has remained unclear due to truncations of ICL3 in all available structures of the β1AR in complex with G or a G protein mimetic nanobody. To address this, we used cell-free cotranslational insertion of full-length human β1AR into nanodiscs and determined its cryo-electron microscopy (cryo-EM) structure in complex with G. In this structure, ICL3 extends transmembrane helix 5, resulting in enhanced interactions with Gα and in a slight rotation of the engaged G protein.
View Article and Find Full Text PDFJ Stomatol Oral Maxillofac Surg
August 2025
Ningbo Stomatology Hospital, Ningbo, Zhejiang, China; School of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, China. Electronic address:
Background: This study aimed to assess the location of disc and the movement characteristic of disc-condyle following disc repositioning operation by bilateral arthroscopic (Bi-ADRO).
Methods: The consecutive patients enrolled, who received magnetic resonance imaging (MRI), 84 patients were included. 31 patients distributing in group N diagnosed as non-ADD.
Sci Rep
August 2025
German Cancer Research Center (DKFZ), Division of Radiology, Heidelberg, Germany.
Despite academic success, radiomics-based machine learning algorithms have not reached clinical practice, partially due to limited repeatability/reproducibility. To address this issue, this work aims to identify a stable subset of radiomics features in prostate MRI for radiomics modelling. A prospective study was conducted in 43 patients who received a clinical MRI examination and a research exam with repetition of T2-weighted and two different diffusion-weighted imaging (DWI) sequences with repositioning in between.
View Article and Find Full Text PDFClin Oral Investig
August 2025
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials
Objectives: To quantitatively analyze potential factors influencing the efficacy of anterior repositioning splint (ARS) therapy in patients with disc displacement with reduction (DDWR), and to explore the prognostic value of MRI-based texture analysis.
Materials And Methods: 82 patients with 140 joints of DDWR were conducted in the retrospective study from 2020 to 2022. The custom maxillary ARS was fabricated based on incisal edge-to-edge occlusal record.
Orthopadie (Heidelb)
August 2025
Abteilung für Orthopädie und Unfallchirurgie, Johanniter Waldkrankenaus Bonn, Waldstr. 73, 53177, Bonn, Deutschland.
Fractures of the tibial head continue to pose a challenge in surgical treatment. The goal is to achieve anatomical repositioning of the joint surface in order to prevent the development of posttraumatic gonarthrosis whenever possible. Sequential imaging techniques, such as computed tomography and magnetic resonance imaging, have become established for identifying the fracture morphology along with associated ligamentous and neurovascular accompanying injuries as well as for determining the treatment regimen, and for planning the surgical intervention.
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