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This study reports the coding-complete genome sequences of three rotavirus A (RVA) reference strains previously adapted in tissue culture: RVA/Mouse-tc/USA/EDIM/XXXX/G16P[16] with a G16-P[16]-I7-R7-C7-M8-A7-N7-T10-E7-H9 genotype constellation, RVA/Human-tc/USA/Ph158/1998/G9P[6] with a G9-P[6]-I2-R2-C2-M2-A2-N2-T2-E2-H2 genotype constellation, and RVA/Human-tc/USA/CC425/1998/G3P[9] with a G3-P[9]-I2-R2-C2-M2-A3-N2-T1-E2-H3 genotype constellation.
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http://dx.doi.org/10.1128/MRA.00630-23 | DOI Listing |
Infect Genet Evol
September 2025
Next Generation Sequencing Unit, School of Biomedical Sciences, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa; Division of Virology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa. Electronic address: N
The sub-Saharan African region bears the highest burden of rotavirus-associated morbidity and mortality, with substantial genetic diversity observed in circulating strains despite vaccine introduction. The G8 genotype, originally predominant in bovine strains, has increasingly become prevalent in humans, suggesting a possible interface of animal-to-human transmission and highlighting its role in African strain diversity. In this study, we performed whole genome sequencing and evolutionary analysis of 21 archival G8P[4] strains collected through gastroenteritis surveillance in South Africa between 2009 and 2021 from children under five years of age.
View Article and Find Full Text PDFViruses
August 2025
Virology Center, Adolfo Lutz Institute, Sao Paulo 01246-902, Brazil.
In Brazil, molecular surveillance expanded after Rotarix™ vaccine introduction, alongside G2P[4] dominance. The G2P[6] genotype, despite sharing the same DS-1-like constellation as G2P[4] strains, remains rare. This retrospective study analyzed eight Brazilian G2P[6] strains (2012-2014) through RT-PCR and 11-segments sequencing, followed by phylogenetic analysis.
View Article and Find Full Text PDFVet Sci
August 2025
National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
Group A rotavirus (RVA) is a leading causative agent of diarrhea in both young animals and humans. In China, multiple genotypes are commonly found within the bovine population. In this study, we investigated 1917 fecal samples from calves with diarrhea between 2022 and 2025, with 695 testing positive for RVA, yielding an overall detection rate of 36.
View Article and Find Full Text PDFCureus
July 2025
Dermatology, Nicklaus Children's Hospital, Children's Skin Center, Miami, USA.
Nicolaides‑Baraitser syndrome (NBS) is an ultrarare SMARCA2‑related neurodevelopmental disorder, whose cutaneous hallmarks traditionally include early hypotrichosis and coarse, sparse scalp hair. We describe a four‑year‑old girl with genetically confirmed NBS who presented with years‑long, worsening eczematous dermatitis and diffuse, non‑scarring alopecia that far exceeded the baseline hypotrichosis described in the syndrome. Clinical examination revealed erythematous, lichenified patches distributed across the trunk, extremities, and flexural creases, accompanied by generalized scalp thinning without follicular dropout or scarring.
View Article and Find Full Text PDFWhen animals reproduce in social groups, the potential for conflict and cooperation is shaped by the number of reproductive individuals (breeders), their relatedness to one another, and division of reproduction among them. These features comprise species' "breeding systems." Despite their importance, breeding systems are poorly characterized in most social animals, and detailed accounts for single species are rare.
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