Neural Crest-Derived Co-localization: A Case of Granular Cell Tumor Arising Beneath a Nevus Spilus.

Granular cell tumors (GCTs) are rare neoplasms believed to originate from Schwann cells, exhibiting immunohistochemical and ultrastructural features consistent with neural crest derivation. Similarly, a nevus spilus (NS) is a pigmented skin lesion composed of lentiginous background macules with superimposed darker macules or papules, also thought to arise from neural crest-derived melanocytes. We report a unique case of a 27-year-old female who presented with a painful subcutaneous nodule on the left medial midback, overlaid by an NS.

Expanding the Cutaneous Spectrum of Nicolaides‑Baraitser Syndrome: Eczema and Generalized Hair Loss.

Nicolaides‑Baraitser syndrome (NBS) is an ultrarare SMARCA2‑related neurodevelopmental disorder, whose cutaneous hallmarks traditionally include early hypotrichosis and coarse, sparse scalp hair. We describe a four‑year‑old girl with genetically confirmed NBS who presented with years‑long, worsening eczematous dermatitis and diffuse, non‑scarring alopecia that far exceeded the baseline hypotrichosis described in the syndrome. Clinical examination revealed erythematous, lichenified patches distributed across the trunk, extremities, and flexural creases, accompanied by generalized scalp thinning without follicular dropout or scarring.

All Twenty Nails Affected: Aripiprazole-Induced Photo-Onycholysis in an 11-Year-Old Boy.

Photo-onycholysis is a phototoxic reaction characterized by separation of the nail plate following light exposure and medication use. While commonly associated with antibiotics and psoralens, newer agents have also been implicated. We present the case of an 11-year-old male who developed diffuse brown discoloration, onycholysis, and onychomadesis of all 20 nails one month after starting liquid aripiprazole.

Keratoacanthoma-Type Invasive Squamous Cell Carcinoma Managed Non-surgically With Topical Immunomodulators.

A rapidly growing lesion with keratoacanthoma-like features may complicate early diagnosis of squamous cell carcinoma (SCC). While most cutaneous SCCs exhibit slow, indolent growth, lesions with keratoacanthoma-like features may demonstrate more rapid expansion, occasionally complicating early diagnosis. We report a case of a 71-year-old male patient with a history of actinic keratoses and non-melanoma skin cancer who presented with a new blistering, erythematous eruption on the left dorsal forearm.

Ophthalmic and Cutaneous Manifestation of Xeroderma Pigmentosum in a 21-Year-Old Man: A Case Report.

Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder characterized by a defect in DNA repair, leading to marked sensitivity to ultraviolet (UV) light, an increased risk of cutaneous malignancies, and frequent ophthalmic complications. We present a 21-year-old man with a history of bilateral ocular melanomas and evolving cutaneous lesions suspicious for malignancy. This report highlights the clinical features, histopathologic considerations, and multidisciplinary management challenges in XP, underscoring the importance of vigilant surveillance, early intervention, and interdisciplinary care.

Novel ANKRD26 and PDGFRB gene mutations in pediatric case of non-Langerhans cell histiocytosis: Case report and literature review.

Cutaneous non-Langerhans cell histiocytosis (NLCH) is a rare and biologically benign entity that can be broadly classified into two categories: xanthogranuloma and non-xanthogranuloma. The xanthogranuloma family is characterized by a proliferation of histiocytes with both macrophage and dendritic cell differentiation, negative BRAF mutation, and rare Touton-type giant cells. Molecular studies have reported that mutations involved in the MAPK signaling pathways are implicated in the pathophysiology of histiocytoses.