Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
A conference on progress in the development of xenotransplantation in China was held in Neijiang, Sichuan, in May 2023, and was attended by approximately 100 established researchers and trainees. Progress in xenotransplantation research was reviewed by both Chinese and foreign experts. The topics discussed ranged from genetic engineering of pigs and the results of pig-to-nonhuman primate organ transplantation to the requirements for designated pathogen-free (DPF) pig facilities and regulation of xenotransplantation. This conference served as an opportunity to collectively advance the development of xenotransplantation in China and pave the way for its clinical application.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/xen.12829 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
3D-Printed Extracellular Matrix-Mimicking Hydrogels Derived from Multiple Tissues for Integrated Construction of Complex Organs.
Adv Healthc Mater
September 2025
Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, China.
Due to the lack of suitable donors and concerns about immune rejection after transplantation, the demand for artificial organs among patients is increasing. Extracellular matrix-mimicking hydrogels provide excellent prospects for overcoming the limitations of current artificial organ construction methods. Here, a set of extracellular matrix-mimicking hydrogels derived from multiple animal tissues is described, which meets the regeneration needs of multiple tissues after xenotransplantation.
View Article and Find Full Text PDFXenotransplantation Literature Update: January-June 2025.
Xenotransplantation
August 2025
Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
From January to June 2025, the field of xenotransplantation progressed rapidly toward clinical translation, with landmark compassionate-use cases, peer-reviewed reports of porcine kidney, heart, and liver transplants in humans, and the release of authoritative international guidelines. This literature update summarizes key developments across clinical trials, immunological insights, donor engineering, preservation strategies, infection control, and ethical frameworks, highlighting a growing consensus on the scientific and regulatory roadmap for safe, effective, and equitable xenotransplantation.
View Article and Find Full Text PDFSerological Assessment of Alpha Galactosidase, N-Glycolylneuraminic Acid, and Histopathological Observations in Xenograft Recipients.
Cureus
August 2025
Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, USA.
Background and aims The alpha-galactosidase (αGal) epitope and the associated anti-Gal antibodies, along with the non-human sialic acid N-glycolylneuraminic acid (Neu5Gc) and its corresponding anti-Neu5Gc antibodies, represent critical obstacles in the field of xenotransplantation. We present an evaluation of serological and histopathological data from patients who experienced immunological rejection after receiving decellularized xenografts. This study aims to analyze the long-term immune responses that occur following the implantation of these grafts, providing insights into the mechanisms driving rejection and their potential impact on transplant outcomes.
View Article and Find Full Text PDFEvolving Paradigms and Future Frontiers In Heart Transplantation in the Modern Era: A State-of-Art Focus Review.
J Card Fail
August 2025
Center for Advanced Heart Disease, Brigham and Women's Hospital and Harvard Medical School, Boston, MA. Electronic address:
Heart transplantation stands at the threshold of a new era shaped by transformative advances across the clinical and scientific continuum. This contemporary review highlights developments with the greatest potential to shift practice and improve patient outcomes. First, evolving strategies in organ preservation and transport- such as ex vivo perfusion and normothermic techniques- are expanding geographic boundaries and optimizing donor heart utilization.
View Article and Find Full Text PDFAnti-CTLA-4 Treatment Abrogates Co-stimulation Blockade-induced Acceptance of Transgenic Porcine Islets in Humanized Mice.
Transplantation
August 2025
Medizinische Klinik und Poliklinik IV, Diabetes Zentrum-Campus Innenstadt, Klinikum der Universität München, Munich, Germany.
Background: In previous studies, we showed that beta cell-specific overexpression of high-affinity variant of human CTLA-4 (LEA29Y), a high-affinity variant of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4)-immunoglobulin, prevented porcine islet rejection in humanized mouse models. We here investigate whether long-term xenograft function and survival is maintained after neutralization of LEA29Y-mediated co-stimulation blockade.
Methods: Diabetic humanized NOD-SCID IL2rγ-/- mice were transplanted with transgenic neonatal porcine islet-like clusters expressing LEA29Y under control of the porcine insulin promoter.