Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Purpose: There has been an association between changes in body composition, fracture incidence, and age in previous studies. Telomere length (TL) has been proposed as a biomarker of aging. However, the relationship between body composition, fractures, and TL has rarely been studied. Therefore, this study aimed to investigate the correlation between TL and body composition and fractures.Patients and methods: 20950 participants from the 2001-2002 National Health and Nutrition Examination Survey (NHANES) were included in the final analysis. In NHANES, body compositions were measured with DXA, and TL was determined with quantitative PCR. Correlation analysis of TL and body composition was conducted using multivariate weighted linear regression and logistic regression models.
Results: The results showed that TL positively correlated with bone mineral density (BMD) and bone mineral content (BMC) in most body parts. However, BMD and BMC were negatively connected with TL in the upper limbs and skull. Fat content was negatively associated with TL, while muscle content was positively linked to TL. In addition, TL's trend analysis results were consistent with the regression model when transformed from a continuous to a classified variable. An increase in TL was associated with a higher incidence of wrist fractures, while a decrease in spine fractures. The above correlation also has a certain degree of sex specificity.
Conclusion: Our study indicate that TL is associated with body composition as well as fractures, but further research is needed to confirm these contrasting associations in the skull, upper limbs, and wrists.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514483 | PMC |
| http://dx.doi.org/10.3389/fimmu.2023.1181544 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Muscle Mass Paradox: Elevated Lean Mass Indices Impair Systolic Function via Myocardial Remodeling in Obesity.
Echocardiography
September 2025
Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Objectives: To explore the relationships between cardiac parameters and body composition indices, identifying predictors of subclinical cardiac systolic dysfunction.
Methods: Using anthropometric and serological parameters, echocardiography, and body composition analysis, this study evaluated metabolic profiles, cardiac remodeling patterns, and body composition characteristics in young adult obese patients, while quantifying the correlations between cardiac parameters and body composition indices. Subclinical left ventricular systolic dysfunction was defined as global longitudinal strain (GLS) < 18%.
Associations of adherence to the World Cancer Research Fund lifestyle recommendations with health-related quality of life and fatigue in Adolescent and Young Adult (AYA) cancer survivors: results from the SURVAYA study.
J Cancer Surviv
September 2025
Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, 6525, GA, The Netherlands.
Purpose: Adolescents and young adults (AYAs) with cancer face unique long-term social and health challenges that impact their health-related quality of life (HRQoL). This study explores the association between lifestyle behaviors (physical activity, body composition, and nutrition) and HRQoL as well as fatigue in AYA cancer survivors.
Methods: The cross-sectional SURVAYA study analyzed data from long-term AYA cancer survivors (5-20 years post diagnosis, aged 18-39 at diagnosis) in The Netherlands.
Mitochondrial membrane remodeling during heat acclimation in Mongolian gerbils.
Mar Life Sci Technol
August 2025
School of Life Sciences, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237 China.
Unlabelled: Mongolian gerbils had high ability to endure both high and cold temperatures. To study the mechanism of high ability for thermal adaptation, gerbils were acclimated to high temperature (30 °C) for 8 weeks, and were measured for metabolic features, body composition as well as mitochondrial content and activities. Lipidomic techniques were used to measure changes in mitochondrial membrane, including potential mitochondrial membrane remodeling during acute thermoregulation in gerbils.
View Article and Find Full Text PDFGeriatric health changes during the COVID-19 pandemic: impacts on body composition and vascular aging.
J Geriatr Cardiol
August 2025
Family Medicine Clinic, Obesity, Metabolism and Nutrition Center and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
Maternal β-carotene addition has long-term effects on intestinal health of offspring chicks.
Front Microbiol
August 2025
College of Animal Science and Technology, College of Veterinary Medicine, Jilin Agricultural University, Changchun, Jilin, China.
Background: Maternal dietary intervention utilizing complex additives rich in β-carotene has demonstrated the capacity to enhance embryonic intestinal development and influence microbial composition in offspring. Nevertheless, the extended impact of maternal β-carotene inclusion on the intestinal health of post-hatching chicks is still not fully elucidated.
Objective: This research aimed to evaluate the impacts of maternal β-carotene supplementation on the intestinal development and microbial communities in chicks after hatching.