The Clinical Impact of Intravascular Imaging-Guided Percutaneous Coronary Intervention in Acute Myocardial Infarction Patients with High Thrombus Burden.

Despite the established clinical efficacy following intravascular imaging (IVI)-guided percutaneous coronary intervention (PCI) than angiography-guided PCI, evidence regarding prognostic benefits of IVI-guided PCI in acute myocardial infarction (AMI) patients with high thrombus burden remains limited. Using the nationwide registries of KAMIR-NIH and KAMIR-V, we evaluated the prognostic impact of IVI-guided PCI in AMI patients with high thrombus burden. A total of 4,074 patients with AMI and TIMI thrombus grades 4 or 5 who underwent aspiration thrombectomy were selected, of whom 892 patients (21.

Immediate versus staged complete revascularisation during index admission in patients with ST-segment elevation myocardial infarction and multivessel disease (OPTION-STEMI): a multicentre, non-inferiority, open-label, randomised trial.

Background: The optimal timing of complete revascularisation for patients with ST-segment elevation myocardial infarction (STEMI) and multivessel coronary artery disease remains unclear. We aimed to assess whether immediate complete revascularisation was non-inferior to staged complete revascularisation during the index admission.

Methods: We conducted an open-label, randomised, non-inferiority trial at 14 hospitals in South Korea.

Impact of the COVID-19 Pandemic on Clinical Outcomes after Hip Fracture Surgery in Elderly Patients.

Purpose: The coronavirus disease 2019 (COVID-19) pandemic led to mandatory screening of hospitalized patients. This study aims to assess the impact of COVID-19 admission delays on clinical outcomes, specifically complications and mortality, in elderly patients following hip fracture surgery.

Materials And Methods: This study included 563 patients (aged ≥70 years) who underwent hip fracture surgery between February 2018 to January 2021 and were followed up for at least one year.

Molecular characterization of tick genera Haemaphysalis, Ixodes, and Amblyomma in Korea.

Ticks are important ectoparasites that serve as key vectors of various pathogens, posing significant risks to both human and animal health. In this study, 3 genera and 5 species of ticks, including Haemaphysalis longicornis, H. flava, H.

Distribution and genotypes of Enterocytozoon bieneusi in raccoon dogs in Korea.

Enterocytozoon is a genus of microsporidian parasites, with Enterocytozoon bieneusi being a well-known species. It infects various mammalian hosts, including humans, and exhibits zoonotic potential. Out of the 97 fecal and intestinal samples collected from wild raccoon dogs in Korea, 12 (12.

Clinical Relevance of Fractional Flow Reserve-Guided Percutaneous Coronary Interevention According to Left Ventricular Ejection Fraction in Patients With Acute Myocardial Infarction and Multivessel Disease.

Background: Fractional flow reserve (FFR)-guided or angiography-guided complete revascularization has not been evaluated in patients with acute myocardial infarction (AMI) with multivessel disease and reduced left ventricular ejection fraction (LVEF). This study sought to evaluate the impact of FFR-guided percutaneous coronary intervention (PCI) for patients with AMI with multivessel disease according to left ventricular systolic function.

Methods: We performed a prespecified analysis of the FRAME-AMI (Fractional Flow Reserve Versus Angiography-Guided Strategy in Acute Myocardial Infarction With Multivessel Disease) trial, which randomly allocated 562 patients to undergo either FFR-guided PCI (FFR ≤0.

Intravascular Imaging-Guided PCI vs Coronary Artery Bypass Grafting for Left Main or 3-Vessel Disease.

Background: Previous trials have shown that coronary artery bypass graft (CABG) has better clinical outcomes compared with percutaneous coronary intervention (PCI) for patients with left main coronary artery or 3-vessel disease. However, it is unclear whether intravascular imaging (IVI)-guided PCI would reduce the difference in clinical events compared to CABG.

Objectives: The present study sought to compare the clinical outcomes of patients with left main or 3-vessel disease who underwent IVI-guided PCI with those who underwent CABG.

Molecular Detection and Genotyping of in Environmental Sources near Cattle Farms in Korea.

, a microsporidian protozoan parasite, infects diverse hosts, including humans and livestock. Transmission occurs primarily through the fecal-oral route or exposure to contaminated environmental sources, such as water and soil. While its prevalence in animals is well documented, data on environmental contamination-particularly in areas surrounding livestock farms-remain limited.

Sacrificial Template-Derived CoMo-LDH Gas Diffusion Electrode for Anion Exchange Membrane Water Electrolysis.

Anion exchange membrane water electrolysis (AEMWE) offers a cost-effective and efficient platform for hydrogen production by enabling the use of non-platinum group metal (non-PGM) electrode materials. However, the sluggish kinetics of the oxygen evolution reaction (OER) remains a key challenge. In this study, a CoMo-LDH OER electrode for AEMWE is developed via a sacrificial template strategy.

Impact of romosozumab treatment for 24 months after switching from denosumab: three case reports.

Prior denosumab use in osteoporosis patients diminishes the BMD gains from a subsequent 12-mo romosozumab regimen. However, few studies have explored BMD gains after 24 mo of romosozumab therapy. BMD at the LS-BMD, FN-BMD, and TH-BMD and P1NP and C-terminal telopeptide of type I collagen (CTX) levels were measured after 24 mo of romosozumab therapy in 3 osteoporosis cases with prior denosumab use.

Chlorogenic acid attenuates cardiac hypertrophy and fibrosis by downregulating galectin 3.

Chlorogenic acid, an ester of caffeic acid and quinic acid, is found in foods such as eggplant and peaches. Its role in heart disease remains poorly understood. This study investigated whether chlorogenic acid affects cardiac hypertrophy and fibrosis in animal and cellular models of isoproterenol-induced cardiac hypertrophy.

Novel artificial intelligence model using electrocardiogram for detecting acute myocardial infarction needing revascularization.

Aims: Rapid myocardial revascularization in patients with acute myocardial infarction (AMI) is essential to improve clinical outcomes. There is still room for improvement in the timely diagnosis of AMI. This study aimed to develop an artificial intelligence (AI) model using electrocardiograms (ECGs) for detecting AMI needing revascularization.

Subclassification of unilateral primary aldosteronism using an optimal cut-off value for positive CYP11B2 (aldosterone synthase) immunohistochemistry and modified histologic criteria in the Korean population.

The histopathology of primary aldosteronism (HISTALDO) consensus indicates the necessity of CYP11B2 (aldosterone synthase) immunostaining in diagnosing primary aldosteronism (PA). However, proper threshold for positive interpretation of CYP11B2 immunostaining is yet to be established. Therefore, we aimed to correlate the subclassification of PA and postsurgical outcomes to define an optimal cut-off value for CYP11B2 immunostaining in 83 unilateral PA patients.

Enhanced Optoelectronic Synaptic Performance in Sol-Gel Derived Al-Doped ZnO Thin Film Devices.

We report the fabrication and characterization of Al-doped ZnO (AZO) optoelectronic synaptic devices based on sol-gel-derived thin films with varying Al concentrations (0~4.0 wt%). Structural and optical analyses reveal that moderate Al doping modulates the crystal orientation, optical bandgap, and defect levels of ZnO films.

Non-culprit Lesion Location and FFR-guided Revascularization in Acute Myocardial Infarction With Multivessel Disease: FRAME-AMI Substudy.

Background And Objectives: The prognosis of unrevascularized non-culprit lesions (NCLs) and the benefits of non-culprit percutaneous coronary intervention (PCI) may depend on their functional significance and location in patients with acute myocardial infarction (AMI) and multivessel coronary disease (MVD). We investigated the differential outcomes of fractional flow reserve (FFR) versus angiography-guided PCI for NCL between the left anterior descending artery (LAD) and non-LAD arteries.

Methods: This was a prespecified post hoc analysis of the FRAME-AMI trial.

Molecular identification and diversity of gastrointestinal apicomplexan protozoa in pigs in the Republic of Korea.

The genera Cryptosporidium, Eimeria, and Cystoisospora cause gastrointestinal diseases in pigs that can lead to economic losses in the pig industry. Despite their importance, the molecular epidemiology and species diversity of these parasites remain poorly understood. Therefore, this study aimed to investigate the distribution and diversity of these genera Cryptosporidium, Eimeria, and Cystoisospora in pigs in Korea and to evaluate their potential influencing factors, including geographical location and season.

Discovery of a Novel , Parahenipavirus_GH, in Shrews in South Korea, 2022.

Highly pathogenic henipaviruses (Nipah and Hendra viruses) and parahenipaviruses (Langya virus) have demonstrated significant zoonotic potential. We aimed to identify or species in rodents and shrews in South Korea to underline the potential zoonotic transmission risk. Kidney and lung tissues from 285 rodents and shrews were screened for and using quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) targeting the Gamak virus and Daeryong virus (DARV) sequences.

Gate-Controlled Three-Terminal ZnO Nanoparticle Optoelectronic Synaptic Devices for In-Sensor Neuromorphic Memory Applications.

This study reports a gate-tunable three-terminal optoelectronic synaptic device based on an Al/ZnO nanoparticles (NPs)/SiO/Si structure for neuromorphic in-sensor memory applications. The ZnO NP film, fabricated via spin coating, exhibited strong UV-induced excitatory post-synaptic current (EPSC) responses that were modulated by gate voltage through charge injection across the SiO dielectric rather than by conventional field effect. Optical stimulation enabled short-term synaptic plasticity, with paired-pulse facilitation (PPF) values reaching 185% at a gate voltage of -5.

Distribution and genotypic analysis of Enterocytozoon bieneusi from cats in Korea.

Enterocytozoon bieneusi is an opportunistic microsporidian parasite with zoonotic potential that causes gastrointestinal illness in humans and animals. This study aimed to investigate the presence and genetic diversity of E. bieneusi from cats in Korea and to assess the potential public health risks associated with zoonotic genotypes.

Synaptic Plasticity and Memory Retention in ZnO-CNT Nanocomposite Optoelectronic Synaptic Devices.

This study presents the fabrication and characterization of ZnO-CNT composite-based optoelectronic synaptic devices via a sol-gel process. By incorporating various concentrations of CNTs (0-2.0 wt%) into ZnO thin films, we investigated their effects on synaptic behaviors under ultraviolet (UV) stimulation.

The Identification of a Glucuronyltransferase-Related Gene, with Putative Mucus Protection and Anti-Inflammatory Effects from Gut-Damaged by Dextran Sulfate Sodium (DSS).

The intestinal epithelium, which is protected by mucosal surfaces composed of mucins and other glycoproteins, functions as a selective barrier that absorbs nutrients while preventing the translocation of harmful substances. To understand the mechanisms between mucosal disruption and tissue inflammation, we orally administrated a mucus-disrupting agent, dextran sodium sulfate, to and screened 63 differentially expressed genes (DEGs). Through a database search using bioinformatics tools (CHEA3 and WebGestalt), we identified ELK1 as a potential key transcription factor for the selected DEGs, and among the 63 DEGs, ELK1-related genes, B3GAT3, FIBP, and TENT2 (, , and in ), were selected as the relevant genes that respond to mucus disruption.

18S rRNA gene metabarcoding for investigation of gastrointestinal parasite diversity in great cormorants.

The great cormorant (Phalacrocorax carbo) is a migratory, fish-eating bird that may act as a carrier for various pathogens, raising potential ecological and public health concerns. This study investigated the diversity of gastrointestinal parasites in great cormorants from the Republic of Korea using 18S rRNA gene metabarcoding and conventional diagnostic methods. Fecal samples were collected from 10 great cormorants in Korea, and DNA was extracted for metabarcoding targeting the V4 and V9 regions of the 18S rRNA gene using the MiSeq platform.

Monolithic GaN-Based Dual-Quantum-Well LEDs with Size-Controlled Color-Tunable White-Light Emission.

We report a monolithic GaN-based light-emitting diode (LED) platform capable of color-tunable white-light emission via LED size scaling. By varying the LED size from 800 µm to 50 µm, the injection current density was effectively controlled under constant driving current, enabling precise modulation of carrier distribution within a dual-composition multi-quantum well (MQW) structure. The active layer consists of five lower InGaN/GaN QWs for blue emission and strain induction, and an upper InGaN/GaN single QW engineered for red-orange emission.

Association between cumulative pack-year smoking exposure and sarcopenia: a KoGES cohort study.

Background: Sarcopenia is the age-related involuntary loss of skeletal muscle mass and strength. Many factors, such as ageing and behaviour, may affect the risk of sarcopenia. However, no study had confirmed the association between cumulative exposure to smoking and the risk of developing sarcopenia.

Newcastle disease virus expressing clade 2.3.4.4b H5 hemagglutinin confers protection against lethal H5N1 highly pathogenic avian influenza in BALB/c mice.

The widespread H5 clade 2.3.4.