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Article Abstract
Introduction: is a species of herb used as a popular food in Vietnam. Furthermore, the species has been used as a Vietnamese traditional medicine to treat many diseases.
Methods: Chemical constituents in the essential oil from leaves of were determined using GC/MS analysis. The anti-gout and anti-diabetic activities of the essential oil were determined through the inhibitory assays against xanthine oxidase, α-glucosidase and α-amylase enzymes. In addition, molecular docking simulations were used to elucidate the inhibitory mechanism between the main compounds and the enzymes.
Results: The dominant constituents of the essential oils were determined as -caryophyllene (20.6%), -bisabolene (11.6%), -selinene (8.4%), -elemene (7.7%), -muurola-4(14),5-diene (7.4%), and ()--ocimene (6.7%). The essential oil displayed xanthine oxidase, -amylase, and -glucosidase inhibitory activities with IC values of 28.4, 130.6, and 59.1 μg/mL, respectively. The anti-gout and anti-diabetic activities of the essential oil from the species are reported for the first time. Furthermore, molecular docking simulation was consistent to experiments.
Conclusion: The present study provides initial evidence that the essential oil of may be a potential natural source to develop new diabetes preparations.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458695 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2023.e19148 | DOI Listing |
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