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Breast cancer represents the most commonly diagnosed neoplasm worldwide and the HER2-positive subtype accounts for nearly 1 in 5 breast cancers. The majority of patients with breast cancer present with an early-stage disease upon diagnosis, which is thus susceptible to virtually curative treatment strategies. For a stage, I T1a/b N0 HER2-positive disease, upfront surgery followed by adjuvant therapy is the preferred approach. However, there is some uncertainty regarding the appropriate management of stage cT1c cN0, as both the neoadjuvant approach and upfront surgery have been proven to be feasible therapeutic options. The aim of this Delphi consensus was to define the best strategies for the treatment of early HER2-positive breast cancer. This work may help clinicians in the management of early HER2-positive breast cancer.
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http://dx.doi.org/10.1016/j.clbc.2023.07.006 | DOI Listing |
J Cell Mol Med
September 2025
College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
Berberine (BBR) is an isoquinoline alkaloid with a variety of biological activities, including anti-microbial and anti-tumoral activities. However, the cellular targets of BBR and the roles of BBR in the radiosensitivity of breast cancer cells are not well defined. In this study, we investigated the effects of BBR on the radiosensitivity of BT549 triple-negative breast cancer cells.
View Article and Find Full Text PDFClin Breast Cancer
August 2025
Department of Pharmacy, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, School of Pharmacy, Fujian Medical University, Fuzhou, China. Electronic address:
Background: Emerging evidence suggests that the gut microbiota (GM) may influence the progression of breast cancer by modulating immune responses. Given the vast diversity of GM and immune cell phenotypes, this study aimed to utilize the most advanced and comprehensive data to explore the causal relationships among the GM, immune cell phenotypes, and survival rates in hormone receptor-positive (HR+) breast cancer patients under different treatment regimens.
Methods: We investigated the causal relationships between the GM, immune cell phenotypes, and survival rates in HR+ breast cancer patients treated with 11 distinct therapeutic strategies using Mendelian randomization.
Acad Radiol
September 2025
Department of General Surgery, Abdulkadir Yuksel State Hospital, Gaziantep, Turkey (A.N.Ş.).
Nihon Hoshasen Gijutsu Gakkai Zasshi
September 2025
Department of Radiological Technology, Faculty of Health Sciences, Gifu University of Medical Science.
Purpose: We aimed to develop an AI-based system to score the positioning in mammography (MG), with the goal of establishing a foundation for future technical support.
Methods: Using 800 mediolateral oblique (MLO) images, we developed an AI model (Mask Generation Model) for automatic extraction of three regions: the pectoralis major muscle, the mammary gland region, and the nipple. Using this model, we extracted three regions from 1544 MLO images and generated mask images.
Anal Chim Acta
November 2025
Department of Breast Surgery, General Surgery Center, First Hospital of Jilin University, Changchun, PR China. Electronic address:
Background: Breast-conserving surgery (BCS) is the primary surgical approach for patients with breast cancer. The accurate determination of surgical margins during BCS is critical for patient prognosis; however, time constraints and limitations in current pathological techniques often prevent pathologists from performing this assessment intraoperatively. The inability to reliably assess margins during surgery can lead to incomplete tumor removal and the need for additional surgeries.
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