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Beyond words and gestures, people have a remarkable capacity to communicate indirectly through everyday objects: A hat on a chair can mean it is occupied, rope hanging across an entrance can mean we should not cross, and objects placed in a closed box can imply they are not ours to take. How do people generate and interpret the communicative meaning of objects? We hypothesized that this capacity is supported by social goal inference, where observers recover what social goal explains an object being placed in a particular location. To test this idea, we study a category of common ad-hoc communicative objects where a small cost is used to signal avoidance. Using computational modeling, we first show that goal inference from indirect physical evidence can give rise to the ability to use object placement to communicate. We then show that people from the U.S. and the Tsimane'-a farming-foraging group native to the Bolivian Amazon-can infer the communicative meaning of object placement in the absence of a pre-existing convention, and that people's inferences are quantitatively predicted by our model. Finally, we show evidence that people can store and retrieve this meaning for use in subsequent encounters, revealing a potential mechanism for how ad-hoc communicative objects become quickly conventionalized. Our model helps shed light on how humans use their ability to interpret other people's behavior to embed social meaning into the physical world.
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http://dx.doi.org/10.1016/j.cognition.2023.105524 | DOI Listing |
J Chem Inf Model
September 2025
College of Agriculture and Biological Science, Dali University, Dali 671000, China.
The E76K mutation in protein tyrosine phosphatase (PTP) SHP2 is a recurrent driver of developmental disorders and cancers, yet the mechanism by which this single-site substitution promotes persistent activation remains elusive. Here, we combine path-based conformational sampling, unbiased molecular dynamics (MD) simulations, Markov state models (MSMs), and neural relational inference (NRI) to elucidate how E76K reshapes the activation landscape and regulatory architecture of SHP2. Using a minimum-action trajectory derived from experimentally determined closed and open structures, we generated representative transition intermediates to guide the unbiased MD simulations.
View Article and Find Full Text PDFFront Hum Neurosci
August 2025
Department of Psychology, Northeastern University, Boston, MA, United States.
Mentalizing skills-the capacity to attribute mental states-play critical roles in word learning during typical language development. In autism, mentalizing difficulties may constrain word-learning pathways, limiting language-acquisition opportunities. We ask how autistic children encode and retrieve novel words and what drives individual differences.
View Article and Find Full Text PDFExp Cell Res
September 2025
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, Guangdong 510080, China. Electronic address:
Background: Chronic rejection is a major cause of long-term kidney allograft failure, characterized by persistent inflammation and progressive fibrosis. Macrophages are central mediators of this process, but their phenotypic heterogeneity and regulatory mechanisms in chronic rejection remain incompletely understood.
Methods: We performed single-cell transcriptomic analysis on renal allograft biopsies from patients with different types of rejection and on a time-course rat model of chronic rejection.
Disabil Rehabil Assist Technol
September 2025
School of Foreign Languages, Ningbo University of Technology, Ningbo, China.
The speech and language rehabilitation are essential to people who have disorders of communication that may occur due to the condition of neurological disorder, developmental delays, or bodily disabilities. With the advent of deep learning, we introduce an improved multimodal rehabilitation pipeline that incorporates audio, video, and text information in order to provide patient-tailored therapy that adapts to the patient. The technique uses a cross-attention fusion multimodal hierarchical transformer architectural model that allows it to jointly design speech acoustics as well as the facial dynamics, lip articulation, and linguistic context.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Epidemiology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.
Background: The Government of Indonesia and UNICEF introduced the Aksi Bergizi Social Behavioral Change Communication (SBCC) intervention to promote healthy dietary behaviors among adolescents. However, no systematic assessment of the Program's effect has been made. The objectives of this study are: 1) to assess the extent to which exposure to the Aksi Bergizi Program is associated with dietary behaviors among secondary school students, and; 2) to assess mediation of the mentioned association by dietary self-efficacy.
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